Phenotype Help

CNL1 / YDR357C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant is resistant to canavanine and thialysine; in systematic studies mutants show reduced competitive fitness and increased sensitivity to rapamycin

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

18 entries for 9 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: cnl1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.965
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
homozygous diploid, competitive growthnull
Allele: cnl1-Δ
S288CTreatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
competitive fitness: increased
systematic mutation setnull
Allele: cnl1-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: cnl1-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
oxidative stress resistance: increased
homozygous diploid, competitive growthnull
Allele: cnl1-Δ
S288C3 mM hydrogen peroxideBrown JA, et al. (2006) PMID:16738548
replicative lifespan: decreased
systematic mutation set null
Allele: cnl1-Δ
S288CDetails: short-lived mutants, one standard deviation below the mean, were identified using an HTP sequencing-based yeast replicative lifespan screen (SEBYL), with pooled cells subject to four rounds of biotin-based sorting to enrich old vs young cells, followed by sequencing to ID mutants and abundance
Yu R, et al. (2021) PMID:33790287
resistance to chemicals: decreased
systematic mutation setnull
Allele: cnl1-Δ
S288C sirolimusDetails: sirolimus is rapamycin
Xie MW, et al. (2005) PMID:15883373
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: cnl1-Δ
S288C200 μg/mL desipramineLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
systematic mutation setnull
Allele: cnl1-Δ
S288C50 ug/ml Congo RedDetails: 1 on a scale of 1 to 3, where 3 indicates the highest sensitivity; growth < wt but > slt2 null
García R, et al. (2015) PMID:26341223
resistance to chemicals: decreased
homozygous diploid, competitive growthnull
Allele: cnl1-Δ
S288C20 uM mechlorethamineBrown JA, et al. (2006) PMID:16738548
Showing 1 to 10 of 18 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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