Phenotype Help

CYM1 / YDR430C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant has abnormal mitochondrial morphology and respiratory growth defects; in systematic studies mutants exhibit reduced competitive fitness and elevated sensitivity to neomycin, hydroxyurea, bleomycin and myriocin; overexpression causes increased frequency of chromosome loss

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

32 entries for 17 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
systematic mutation setoverexpressionOtherAssay: a-like faker (ALF) assay
Details: dosage chromosome instability (dCIN) involving chromosome loss, rearrangement and/or gene conversion events
Duffy S, et al. (2016) PMID:27551064
chromosome/plasmid maintenance: decreased
systematic mutation setoverexpressionOtherAssay: chromosome transmission fidelity (CTF) assay
Details: dosage chromosome instability (dCIN) involving chromosome loss
Duffy S, et al. (2016) PMID:27551064
competitive fitness: decreased
competitive growth overexpressionS288CDetails: decreased abundance within the barFLEX overexpression collection arrayed after 20 generations of pooled growth
Douglas AC, et al. (2012) PMID:23050238
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: cym1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.999
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: cym1-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: cym1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0022
Pir P, et al. (2012) PMID:22244311
heat sensitivity: increased
homozygous diploid, systematic mutation set

pooled screening for fitness defects at 37 deg C relative to 30 deg C

null
Allele: cym1-Δ
S288CTemperature: elevated temperature, 37 °C
Sinha H, et al. (2008) PMID:18780730
mitochondrial genome maintenance: abnormal
large-scale surveynull
Allele: cym1-Δ
S288CDetails: decreased frequency of spontaneous mitochondrial genome loss
Hess DC, et al. (2009) PMID:19300474
mitochondrial morphology: abnormal
classical geneticsnull
Allele: cym1-Δ
OtherJønson L, et al. (2004) PMID:15606766
protein activity: decreased
Reporter: Sod2p
classical genetics null
Allele: cym1-Δ
S288CJensen LT, et al. (2019) PMID:30938873
Showing 1 to 10 of 32 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


Resources