VPS52 / YDR484W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VPS52/YDR484W is a non-essential gene; null mutants are viable but exhibit a wide range of phenotypes including decreased resistance to both acidic and alkaline pH, abnormal actin cytoskeleton morphology, decreased anaerobic growth, abnormal and decreased autophagy, abnormal colony appearance, decreased competitive fitness, decreased desiccation resistance, increased heat sensitivity, decreased resistance to hydrostatic pressure and ionic stress, decreased killer toxin resistance, abnormal meiosis, decreased metal resistance, abnormal mitochondrial morphology, increased oxidative stress resistance, decreased small molecule transport, decreased sporulation efficiency, decreased stress resistance, decreased toxin resistance, impaired nitrogen source utilization, decreased UV resistance, abnormal vacuolar morphology, decreased vegetative growth rate, and decreased viability.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources