GUP1 / YGL084C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

GUP1/YGL084C is a non-essential gene; null mutants are viable but exhibit a range of phenotypes including decreased anaerobic growth, abnormal budding pattern, abnormal cell shape, decreased cell size, abnormal cell wall morphology, increased chitin deposition, decreased chronological lifespan, decreased competitive fitness, decreased endocytosis, increased heat sensitivity, decreased hyperosmotic stress resistance, abnormal liquid culture appearance, decreased metal resistance, increased necrotic cell death, decreased nutrient uptake, increased oxidative stress resistance, abnormal plasma membrane morphology, absent or decreased rate of respiratory growth, increased RNA accumulation, decreased small molecule transport, decreased telomere length, decreased toxin resistance, and abnormal vacuolar morphology. Overexpression of GUP1 results in abnormal endomembrane system morphology.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources