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MSB2 / YGR014W Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Cromie GA, et al. (2024) Spatiotemporal patterns of gene expression during development of a complex colony morphology. PLoS One 19(12):e0311061 PMID:39637084
- Vandermeulen MD and Cullen PJ (2023) Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components. mSphere 8(5):e0028423 PMID:37732804
- Lin Z, et al. (2021) Multi-omics based strategy for toxicity analysis of acrylamide in Saccharomyces cerevisiae model. Chem Biol Interact 349:109682 PMID:34610338
- Prabhakar A, et al. (2021) Spatiotemporal control of pathway sensors and cross-pathway feedback regulate a differentiation MAPK pathway in yeast. J Cell Sci 134(15) PMID:34347092
- Chow J, et al. (2019) Aggregate Filamentous Growth Responses in Yeast. mSphere 4(2) PMID:30842272
- Chow J, et al. (2018) Impact of Fungal MAPK Pathway Targets on the Cell Wall. J Fungi (Basel) 4(3) PMID:30096860
- Sukegawa Y, et al. (2018) Genetic dissection of the signaling pathway required for the cell wall integrity checkpoint. J Cell Sci 131(13) PMID:29853633
- Delarue M, et al. (2017) SCWISh network is essential for survival under mechanical pressure. Proc Natl Acad Sci U S A 114(51):13465-13470 PMID:29187529
- Martí-Raga M, et al. (2017) Genetic Causes of Phenotypic Adaptation to the Second Fermentation of Sparkling Wines in Saccharomyces cerevisiae. G3 (Bethesda) 7(2):399-412 PMID:27903630
- Basu S, et al. (2016) Spatial landmarks regulate a Cdc42-dependent MAPK pathway to control differentiation and the response to positional compromise. Proc Natl Acad Sci U S A 113(14):E2019-28 PMID:27001830
- Capurso D, et al. (2016) Discovering hotspots in functional genomic data superposed on 3D chromatin configuration reconstructions. Nucleic Acids Res 44(5):2028-35 PMID:26869583
- Golla U, et al. (2016) Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model. Sci Rep 6:35322 PMID:27734932
- Nishimura A, et al. (2016) Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. Mol Cell Biol 36(7):1109-23 PMID:26787842
- Yamamoto K, et al. (2016) Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Mol Cell Biol 36(3):475-87 PMID:26598606
- Adhikari H and Cullen PJ (2015) Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway. Eukaryot Cell 14(4):427-40 PMID:25724886
- Adhikari H, et al. (2015) Comparative Analysis of Transmembrane Regulators of the Filamentous Growth Mitogen-Activated Protein Kinase Pathway Uncovers Functional and Regulatory Differences. Eukaryot Cell 14(9):868-83 PMID:26116211
- Zuzuarregui A, et al. (2015) Msb2 is a Ste11 membrane concentrator required for full activation of the HOG pathway. Biochim Biophys Acta 1849(6):722-30 PMID:25689021
- Singh V, et al. (2014) Anti-cancer drug KP1019 induces Hog1 phosphorylation and protein ubiquitylation in Saccharomyces cerevisiae. Eur J Pharmacol 736:77-85 PMID:24797784
- Tanaka K, et al. (2014) Yeast osmosensors Hkr1 and Msb2 activate the Hog1 MAPK cascade by different mechanisms. Sci Signal 7(314):ra21 PMID:24570489
- Ask M, et al. (2013) The influence of HMF and furfural on redox-balance and energy-state of xylose-utilizing Saccharomyces cerevisiae. Biotechnol Biofuels 6(1):22 PMID:23409974
- Li Y, et al. (2013) Molecular cloning and evolutionary analysis of the HOG-signaling pathway genes from Saccharomyces cerevisiae rice wine isolates. Biochem Genet 51(3-4):296-305 PMID:23338673
- Shively CA, et al. (2013) Genetic networks inducing invasive growth in Saccharomyces cerevisiae identified through systematic genome-wide overexpression. Genetics 193(4):1297-310 PMID:23410832
- Karunanithi S, et al. (2012) Regulation of mat responses by a differentiation MAPK pathway in Saccharomyces cerevisiae. PLoS One 7(4):e32294 PMID:22496730
- Chavel CA, et al. (2010) Multiple signals converge on a differentiation MAPK pathway. PLoS Genet 6(3):e1000883 PMID:20333241
- Abdullah U and Cullen PJ (2009) The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Eukaryot Cell 8(9):1362-72 PMID:19633267
- Birkaya B, et al. (2009) Role of the cell wall integrity and filamentous growth mitogen-activated protein kinase pathways in cell wall remodeling during filamentous growth. Eukaryot Cell 8(8):1118-33 PMID:19502582
- Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14 PMID:19439450
- Yang HY, et al. (2009) Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK. EMBO J 28(10):1380-91 PMID:19369942
- Vadaie N, et al. (2008) Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast. J Cell Biol 181(7):1073-81 PMID:18591427
- Tatebayashi K, et al. (2007) Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J 26(15):3521-33 PMID:17627274
- Devit M, et al. (2005) Forcing interactions as a genetic screen to identify proteins that exert a defined activity. Genome Res 15(4):560-5 PMID:15805496
- Clevers H (2004) Signaling mucins in the (S)limelight. Dev Cell 7(2):150-1 PMID:15296711
- Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708 PMID:15256499
- Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 PMID:14574415
- O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 PMID:12052881
- Bender A and Pringle JR (1992) A Ser/Thr-rich multicopy suppressor of a cdc24 bud emergence defect. Yeast 8(4):315-23 PMID:1514328
- Bender A and Pringle JR (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80 PMID:2690082
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Tan LR, et al. (2022) Genome-wide transcriptional regulation in Saccharomyces cerevisiae in response to carbon dioxide. FEMS Yeast Res 22(1) PMID:35640892
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Peltier E, et al. (2021) Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation. Front Fungal Biol 2:733513 PMID:37744152
- Kuo CY, et al. (2020) The High Osmolarity Glycerol (HOG) Pathway Functions in Osmosensing, Trap Morphogenesis and Conidiation of the Nematode-Trapping Fungus Arthrobotrys oligospora. J Fungi (Basel) 6(4) PMID:32992476
- Linder RA, et al. (2020) Two Synthetic 18-Way Outcrossed Populations of Diploid Budding Yeast with Utility for Complex Trait Dissection. Genetics 215(2):323-342 PMID:32241804
- Prabhakar A, et al. (2020) Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway in S. cerevisiae. J Cell Sci 133(7) PMID:32079658
- Silva LP, et al. (2020) Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources. mSphere 5(5) PMID:32938702
- Prabhakar A, et al. (2019) Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include a Regulator of the Actin Cytoskeleton. Biochemistry 58(48):4842-4856 PMID:31710471
- Diepeveen ET, et al. (2018) Patterns of Conservation and Diversification in the Fungal Polarization Network. Genome Biol Evol 10(7):1765-1782 PMID:29931311
- Riggi M, et al. (2018) Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2. Nat Cell Biol 20(9):1043-1051 PMID:30154550
- Nasution O, et al. (2017) Overexpression of OLE1 enhances stress tolerance and constitutively activates the MAPK HOG pathway in Saccharomyces cerevisiae. Biotechnol Bioeng 114(3):620-631 PMID:27596631
- Konte T, et al. (2016) Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae. Front Microbiol 7:901 PMID:27379041
- Adhikari H, et al. (2015) Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway. Mol Cell Biol 35(8):1414-32 PMID:25666509
- Cullen PJ (2015) Evaluating the activity of the filamentous growth mitogen-activated protein kinase pathway in yeast. Cold Spring Harb Protoc 2015(3):276-83 PMID:25734070
- Hirschmann WD, et al. (2014) Scp160p is required for translational efficiency of codon-optimized mRNAs in yeast. Nucleic Acids Res 42(6):4043-55 PMID:24445806
- van der Felden J, et al. (2014) The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. Mol Cell Biol 34(12):2283-93 PMID:24732795
- Lien EC, et al. (2013) Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Biochemistry 52(1):115-24 PMID:23210626
- Breidenbach MA, et al. (2012) Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics 11(6):M111.015339 PMID:22261724
- Miyamoto M, et al. (2012) The high-osmolarity glycerol- and cell wall integrity-MAP kinase pathways of Saccharomyces cerevisiae are involved in adaptation to the action of killer toxin HM-1. Yeast 29(11):475-85 PMID:23065846
- Calahan D, et al. (2011) Genetic analysis of desiccation tolerance in Sachharomyces cerevisiae. Genetics 189(2):507-19 PMID:21840858
- Jung PP, et al. (2011) Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae. BMC Genomics 12:331 PMID:21711526
- Thorne TW, et al. (2011) Prediction of putative protein interactions through evolutionary analysis of osmotic stress response in the model yeast Saccharomyces cerevisae. Fungal Genet Biol 48(5):504-11 PMID:21193057
- Villa-García MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PMID:21136082
- Cooper SJ, et al. (2010) High-throughput profiling of amino acids in strains of the Saccharomyces cerevisiae deletion collection. Genome Res 20(9):1288-96 PMID:20610602
- Karunanithi S, et al. (2010) Shedding of the mucin-like flocculin Flo11p reveals a new aspect of fungal adhesion regulation. Curr Biol 20(15):1389-95 PMID:20619652
- Lanver D, et al. (2010) Sho1 and Msb2-related proteins regulate appressorium development in the smut fungus Ustilago maydis. Plant Cell 22(6):2085-101 PMID:20587773
- Wang YC and Chen BS (2010) Integrated cellular network of transcription regulations and protein-protein interactions. BMC Syst Biol 4:20 PMID:20211003
- Wolf JJ, et al. (2010) Feed-forward regulation of a cell fate determinant by an RNA-binding protein generates asymmetry in yeast. Genetics 185(2):513-22 PMID:20382833
- Wu CY, et al. (2010) Control of transcription by cell size. PLoS Biol 8(11):e1000523 PMID:21072241
- Wu X, et al. (2010) The evolutionary rate variation among genes of HOG-signaling pathway in yeast genomes. Biol Direct 5:46 PMID:20618989
- Krantz M, et al. (2009) Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway. Mol Syst Biol 5:281 PMID:19536204
- Parmar JH, et al. (2009) A model-based study delineating the roles of the two signaling branches of Saccharomyces cerevisiae, Sho1 and Sln1, during adaptation to osmotic stress. Phys Biol 6(3):036019 PMID:19657148
- Rintala E, et al. (2009) Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. BMC Genomics 10:461 PMID:19804647
- Roberts GG and Hudson AP (2009) Rsf1p is required for an efficient metabolic shift from fermentative to glycerol-based respiratory growth in S. cerevisiae. Yeast 26(2):95-110 PMID:19235764
- Hannay K, et al. (2008) Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. BMC Genomics 9:609 PMID:19087332
- Hogan DJ, et al. (2008) Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol 6(10):e255 PMID:18959479
- Chou S, et al. (2006) Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol 26(13):4794-805 PMID:16782869
- Gandhi M, et al. (2006) Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Genetics 174(2):665-78 PMID:16816427
- Krantz M, et al. (2006) Comparative genomics of the HOG-signalling system in fungi. Curr Genet 49(3):137-51 PMID:16468042
- Bean JM, et al. (2005) High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae. Genetics 171(1):49-61 PMID:15965243
- Bowen S, et al. (2005) Patterns of polymorphism and divergence in stress-related yeast proteins. Yeast 22(8):659-68 PMID:16032761
- Flatauer LJ, et al. (2005) Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol Cell Biol 25(5):1793-803 PMID:15713635
- Verstrepen KJ, et al. (2005) Intragenic tandem repeats generate functional variability. Nat Genet 37(9):986-90 PMID:16086015
- Zeitlinger J, et al. (2003) Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell 113(3):395-404 PMID:12732146
- Iyer VR, et al. (2001) Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature 409(6819):533-8 PMID:11206552
- Simon I, et al. (2001) Serial regulation of transcriptional regulators in the yeast cell cycle. Cell 106(6):697-708 PMID:11572776
- Rieger M, et al. (1997) Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII. Yeast 13(11):1077-90 PMID:9290212
Reviews
No reviews curated.
Download References (.nbib)
- Du G, et al. (2025) The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses in Saccharomyces cerevisiae. Front Cell Dev Biol 13:1522294 PMID:40129568
- Vandermeulen MD, et al. (2024) Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation. Genetics 228(2) PMID:39239926
- Wang D, et al. (2024) Fungal biofilm formation and its regulatory mechanism. Heliyon 10(12):e32766 PMID:38988529
- Kulshrestha A and Gupta P (2023) Secreted aspartyl proteases family: a perspective review on the regulation of fungal pathogenesis. Future Microbiol 18:295-309 PMID:37097060
- Sęk W, et al. (2023) Physiological and genetic regulation of anhydrobiosis in yeast cells. Arch Microbiol 205(10):348 PMID:37782422
- Blomberg A (2022) Yeast osmoregulation - glycerol still in pole position. FEMS Yeast Res 22(1) PMID:35927716
- Municio-Diaz C, et al. (2022) Mechanobiology of the cell wall - insights from tip-growing plant and fungal cells. J Cell Sci 135(21) PMID:36326245
- Shen D, et al. (2022) A review of yeast: High cell-density culture, molecular mechanisms of stress response and tolerance during fermentation. FEMS Yeast Res 22(1) PMID:36288242
- Yoshimi A, et al. (2022) Cell Wall Integrity and Its Industrial Applications in Filamentous Fungi. J Fungi (Basel) 8(5) PMID:35628691
- de Nadal E and Posas F (2022) The HOG pathway and the regulation of osmoadaptive responses in yeast. FEMS Yeast Res 22(1) PMID:35254447
- Brink DP, et al. (2021) D-Xylose Sensing in Saccharomyces cerevisiae: Insights from D-Glucose Signaling and Native D-Xylose Utilizers. Int J Mol Sci 22(22) PMID:34830296
- Kumar A (2021) The Complex Genetic Basis and Multilayered Regulatory Control of Yeast Pseudohyphal Growth. Annu Rev Genet 55:1-21 PMID:34280314
- Plemenitaš A (2021) Sensing and Responding to Hypersaline Conditions and the HOG Signal Transduction Pathway in Fungi Isolated from Hypersaline Environments: Hortaea werneckii and Wallemia ichthyophaga. J Fungi (Basel) 7(11) PMID:34829275
- Van Drogen F, et al. (2020) Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast. Cell Cycle 19(14):1707-1715 PMID:32552303
- Day AM and Quinn J (2019) Stress-Activated Protein Kinases in Human Fungal Pathogens. Front Cell Infect Microbiol 9:261 PMID:31380304
- Holt S, et al. (2019) The molecular biology of fruity and floral aromas in beer and other alcoholic beverages. FEMS Microbiol Rev 43(3):193-222 PMID:30445501
- Cohen BE (2018) Membrane Thickness as a Key Factor Contributing to the Activation of Osmosensors and Essential Ras Signaling Pathways. Front Cell Dev Biol 6:76 PMID:30087894
- Auesukaree C (2017) Molecular mechanisms of the yeast adaptive response and tolerance to stresses encountered during ethanol fermentation. J Biosci Bioeng 124(2):133-142 PMID:28427825
- Gopinath RK and Leu JY (2017) Hsp90 mediates the crosstalk between galactose metabolism and cell morphology pathways in yeast. Curr Genet 63(1):23-27 PMID:27209632
- Van Dijck P, et al. (2017) Nutrient Sensing at the Plasma Membrane of Fungal Cells. Microbiol Spectr 5(2) PMID:28256189
- Hamann T (2015) The plant cell wall integrity maintenance mechanism--a case study of a cell wall plasma membrane signaling network. Phytochemistry 112:100-9 PMID:25446233
- Brewster JL and Gustin MC (2014) Hog1: 20 years of discovery and impact. Sci Signal 7(343):re7 PMID:25227612
- Saxena A and Sitaraman R (2014) Osmoregulation and the human mycobiome. Front Microbiol 5:167 PMID:24860554
- Free SJ (2013) Fungal cell wall organization and biosynthesis. Adv Genet 81:33-82 PMID:23419716
- Brückner S and Mösch HU (2012) Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae. FEMS Microbiol Rev 36(1):25-58 PMID:21521246
- Cullen PJ and Sprague GF (2012) The regulation of filamentous growth in yeast. Genetics 190(1):23-49 PMID:22219507
- Hamel LP, et al. (2012) Mitogen-activated protein kinase signaling in plant-interacting fungi: distinct messages from conserved messengers. Plant Cell 24(4):1327-51 PMID:22517321
- Howell AS and Lew DJ (2012) Morphogenesis and the cell cycle. Genetics 190(1):51-77 PMID:22219508
- Kühn C and Klipp E (2012) Zooming in on yeast osmoadaptation. Adv Exp Med Biol 736:293-310 PMID:22161336
- Saito H and Posas F (2012) Response to hyperosmotic stress. Genetics 192(2):289-318 PMID:23028184
- Cullen PJ (2011) Post-translational regulation of signaling mucins. Curr Opin Struct Biol 21(5):590-6 PMID:21889329
- Miermont A, et al. (2011) The Dynamical Systems Properties of the HOG Signaling Cascade. J Signal Transduct 2011:930940 PMID:21637384
- Rodríguez-Peña JM, et al. (2010) The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes. Yeast 27(8):495-502 PMID:20641030
- Saito H (2010) Regulation of cross-talk in yeast MAPK signaling pathways. Curr Opin Microbiol 13(6):677-83 PMID:20880736
- Smith DA, et al. (2010) Stress signalling to fungal stress-activated protein kinase pathways. FEMS Microbiol Lett 306(1):1-8 PMID:20345377
- Hohmann S (2009) Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae. FEBS Lett 583(24):4025-9 PMID:19878680
- Chen RE and Thorner J (2007) Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1773(8):1311-40 PMID:17604854
- Clotet J and Posas F (2007) Control of cell cycle in response to osmostress: lessons from yeast. Methods Enzymol 428:63-76 PMID:17875412
- de Nadal E, et al. (2007) Mucins, osmosensors in eukaryotic cells? Trends Cell Biol 17(12):571-4 PMID:17981467
- Bardwell L (2006) Mechanisms of MAPK signalling specificity. Biochem Soc Trans 34(Pt 5):837-41 PMID:17052210
- Slaughter B and Li R (2006) Toward a molecular interpretation of the surface stress theory for yeast morphogenesis. Curr Opin Cell Biol 18(1):47-53 PMID:16337116
- Truckses DM, et al. (2004) Jekyll and Hyde in the microbial world. Science 306(5701):1509-11 PMID:15567850
- Westfall PJ, et al. (2004) When the stress of your environment makes you go HOG wild. Science 306(5701):1511-2 PMID:15567851
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14 PMID:19439450
- Vadaie N, et al. (2008) Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast. J Cell Biol 181(7):1073-81 PMID:18591427
- Tatebayashi K, et al. (2007) Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J 26(15):3521-33 PMID:17627274
- Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708 PMID:15256499
- O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 PMID:12052881
- Bender A and Pringle JR (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80 PMID:2690082
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Cromie GA, et al. (2024) Spatiotemporal patterns of gene expression during development of a complex colony morphology. PLoS One 19(12):e0311061 PMID:39637084
- Prabhakar A, et al. (2020) Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway in S. cerevisiae. J Cell Sci 133(7) PMID:32079658
- Chow J, et al. (2018) Impact of Fungal MAPK Pathway Targets on the Cell Wall. J Fungi (Basel) 4(3) PMID:30096860
- Golla U, et al. (2016) Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model. Sci Rep 6:35322 PMID:27734932
- Shively CA, et al. (2013) Genetic networks inducing invasive growth in Saccharomyces cerevisiae identified through systematic genome-wide overexpression. Genetics 193(4):1297-310 PMID:23410832
- Abdullah U and Cullen PJ (2009) The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Eukaryot Cell 8(9):1362-72 PMID:19633267
- Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14 PMID:19439450
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Kelbert M, et al. (2024) The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay. Elife 12 PMID:39356734
- Meyer L, et al. (2023) eIF2A represses cell wall biogenesis gene expression in Saccharomyces cerevisiae. PLoS One 18(11):e0293228 PMID:38011112
- Bayne RA, et al. (2022) Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site. Nucleic Acids Res 50(5):2923-2937 PMID:34302485
- Chang Y, et al. (2021) Analysis of the TORC1 interactome reveals a spatially distinct function of TORC1 in mRNP complexes. J Cell Biol 220(4) PMID:33566094
- Prabhakar A, et al. (2020) Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway in S. cerevisiae. J Cell Sci 133(7) PMID:32079658
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Prabhakar A, et al. (2019) Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include a Regulator of the Actin Cytoskeleton. Biochemistry 58(48):4842-4856 PMID:31710471
- Iacovella MG, et al. (2018) Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Nucleic Acids Res 46(15):7586-7611 PMID:30011030
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Jungfleisch J, et al. (2017) A novel translational control mechanism involving RNA structures within coding sequences. Genome Res 27(1):95-106 PMID:27821408
- Lapointe CP, et al. (2017) Architecture and dynamics of overlapped RNA regulatory networks. RNA 23(11):1636-1647 PMID:28768715
- Babour A, et al. (2016) The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Cell 167(5):1201-1214.e15 PMID:27863241
- Basu S, et al. (2016) Spatial landmarks regulate a Cdc42-dependent MAPK pathway to control differentiation and the response to positional compromise. Proc Natl Acad Sci U S A 113(14):E2019-28 PMID:27001830
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Shin JJ, et al. (2016) Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech 9(9):1039-49 PMID:27519690
- Srivas R, et al. (2016) A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Mol Cell 63(3):514-25 PMID:27453043
- Yamamoto K, et al. (2016) Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Mol Cell Biol 36(3):475-87 PMID:26598606
- Adhikari H and Cullen PJ (2015) Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway. Eukaryot Cell 14(4):427-40 PMID:25724886
- Adhikari H, et al. (2015) Comparative Analysis of Transmembrane Regulators of the Filamentous Growth Mitogen-Activated Protein Kinase Pathway Uncovers Functional and Regulatory Differences. Eukaryot Cell 14(9):868-83 PMID:26116211
- Adhikari H, et al. (2015) Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway. Mol Cell Biol 35(8):1414-32 PMID:25666509
- Lam MH, et al. (2015) A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae. J Mol Biol 427(11):2088-103 PMID:25644660
- Lapointe CP, et al. (2015) Protein-RNA networks revealed through covalent RNA marks. Nat Methods 12(12):1163-70 PMID:26524240
- Zuzuarregui A, et al. (2015) Msb2 is a Ste11 membrane concentrator required for full activation of the HOG pathway. Biochim Biophys Acta 1849(6):722-30 PMID:25689021
- Hirschmann WD, et al. (2014) Scp160p is required for translational efficiency of codon-optimized mRNAs in yeast. Nucleic Acids Res 42(6):4043-55 PMID:24445806
- Tanaka K, et al. (2014) Yeast osmosensors Hkr1 and Msb2 activate the Hog1 MAPK cascade by different mechanisms. Sci Signal 7(314):ra21 PMID:24570489
- Freeberg MA, et al. (2013) Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biol 14(2):R13 PMID:23409723
- Lien EC, et al. (2013) Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Biochemistry 52(1):115-24 PMID:23210626
- Surma MA, et al. (2013) A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell 51(4):519-30 PMID:23891562
- Karunanithi S and Cullen PJ (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87 PMID:22904036
- Karunanithi S, et al. (2012) Regulation of mat responses by a differentiation MAPK pathway in Saccharomyces cerevisiae. PLoS One 7(4):e32294 PMID:22496730
- Li SC, et al. (2012) Vacuolar H+-ATPase works in parallel with the HOG pathway to adapt Saccharomyces cerevisiae cells to osmotic stress. Eukaryot Cell 11(3):282-91 PMID:22210831
- Sharifpoor S, et al. (2012) Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 22(4):791-801 PMID:22282571
- Chavel CA, et al. (2010) Multiple signals converge on a differentiation MAPK pathway. PLoS Genet 6(3):e1000883 PMID:20333241
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Yamamoto K, et al. (2010) Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor. Mol Cell 40(1):87-98 PMID:20932477
- Abdullah U and Cullen PJ (2009) The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Eukaryot Cell 8(9):1362-72 PMID:19633267
- Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14 PMID:19439450
- Yang HY, et al. (2009) Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK. EMBO J 28(10):1380-91 PMID:19369942
- Hasegawa Y, et al. (2008) Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. RNA 14(11):2333-47 PMID:18805955
- Tarassov K, et al. (2008) An in vivo map of the yeast protein interactome. Science 320(5882):1465-70 PMID:18467557
- Vadaie N, et al. (2008) Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast. J Cell Biol 181(7):1073-81 PMID:18591427
- Tatebayashi K, et al. (2007) Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J 26(15):3521-33 PMID:17627274
- Gandhi M, et al. (2006) Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Genetics 174(2):665-78 PMID:16816427
- Miller JP, et al. (2005) Large-scale identification of yeast integral membrane protein interactions. Proc Natl Acad Sci U S A 102(34):12123-8 PMID:16093310
- Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708 PMID:15256499
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- O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 PMID:12052881
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Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
Download References (.nbib)
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Zhou X, et al. (2021) Cross-compartment signal propagation in the mitotic exit network. Elife 10 PMID:33481703
- MacGilvray ME, et al. (2020) Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res 19(8):3405-3417 PMID:32597660
- Chen YC, et al. (2018) Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife 7 PMID:30516470
- Swaney DL, et al. (2013) Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 10(7):676-82 PMID:23749301
- Holt LJ, et al. (2009) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325(5948):1682-6 PMID:19779198
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Songdech P, et al. (2024) Increased production of isobutanol from xylose through metabolic engineering of Saccharomyces cerevisiae overexpressing transcription factor Znf1 and exogenous genes. FEMS Yeast Res 24 PMID:38331422
- Coey CT and Clark DJ (2022) A systematic genome-wide account of binding sites for the model transcription factor Gcn4. Genome Res 32(2):367-377 PMID:34916251
- Kuang Z, et al. (2017) Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth. Elife 6 PMID:28949295
- O'Connor ST, et al. (2012) Genome-Wide Functional and Stress Response Profiling Reveals Toxic Mechanism and Genes Required for Tolerance to Benzo[a]pyrene in S. cerevisiae. Front Genet 3:316 PMID:23403841
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Villa-García MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PMID:21136082
- Cooper SJ, et al. (2010) High-throughput profiling of amino acids in strains of the Saccharomyces cerevisiae deletion collection. Genome Res 20(9):1288-96 PMID:20610602
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- MacIsaac KD, et al. (2006) An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 7:113 PMID:16522208
- Sopko R, et al. (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21(3):319-30 PMID:16455487
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549