VMA7 / YGR020C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VMA7/YGR020C is a non-essential gene; null mutants are viable and exhibit several notable mutant phenotypes that impact various physiological traits. Mutants lacking this gene demonstrate a decreased resistance to both acidic and alkaline pH levels, indicating a compromised ability to thrive in diverse environmental conditions. Additionally, these mutants display abnormal bud morphology, which may affect their reproductive success. The chronological lifespan of VMA7 mutants is also reduced, suggesting that the gene plays a role in longevity. Competitive fitness is impaired in these mutants, leading to decreased viability in environments where competition for resources is high. Furthermore, their resistance to desiccation and freeze-thaw cycles is diminished, highlighting vulnerabilities to extreme conditions. Heat sensitivity is increased in VMA7 mutants, making them more susceptible to elevated temperatures. They also show decreased resistance to hyperosmotic stress, oxidative stress, and ultraviolet radiation, further underscoring their compromised resilience. The morphology of lipid particles is abnormal in these mutants, which may have implications for cellular metabolism. Overall, vegetative growth is observed to occur at a decreased rate, indicating that the absence of VMA7 significantly impacts the organism's overall fitness and adaptability, although the mutants remain viable.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources