VMA21 / YGR105W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VMA21/YGR105W is a non-essential gene; null mutants are viable but exhibit a range of phenotypic changes including delayed fermentative metabolism, decreased gamma ray resistance, decreased metal resistance, decreased oxidative stress resistance, decreased replicative lifespan, altered resistance to chemicals, absent or decreased respiratory growth rate, decreased alkaline pH resistance, auxotrophy, decreased chronological lifespan, decreased competitive fitness, decreased desiccation resistance, decreased freeze-thaw resistance, decreased hyperosmotic stress resistance, decreased innate thermotolerance, decreased mitotic recombination, increased mutation frequency, decreased resistance to enzymatic treatment, decreased toxin resistance, decreased utilization of carbon and iron sources, abnormal vacuolar morphology, and decreased vegetative growth rate. Reduction of function mutants show decreased acid and alkaline pH resistance. Overexpression of VMA21 results in increased invasive growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources