TIF4631 / YGR162W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

TIF4631/YGR162W null mutants exhibit increased cold and heat sensitivity, decreased nuclear export, decreased protein/peptide accumulation, increased replicative lifespan, altered resistance to various chemicals, and decreased vegetative growth rate. They also show auxotrophy, abnormal bud morphology, delayed cell cycle progression in the G1 phase, abnormal and decreased desiccation resistance, slow growth, increased oxidative stress resistance, absent or decreased sporulation, increased stress resistance, decreased toxin resistance, and increased transposable element transposition. Conditional mutants of TIF4631 display increased cold and heat sensitivity and decreased vegetative growth. Overexpression of TIF4631 results in decreased growth rate during the exponential phase, decreased vegetative growth rate, abnormal cell cycle progression, decreased competitive fitness, increased heat sensitivity, decreased hyperosmotic stress resistance, increased invasive growth, decreased metal resistance, decreased resistance to chemicals, increased toxin resistance, and decreased UV resistance. Reduction of function mutants show increased heat sensitivity and decreased vegetative growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources