SMI1 / YGR229C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

SMI1/YGR229C is a non-essential gene; null mutants are viable and exhibit a range of phenotypes including abnormal cell wall morphology, increased chitin deposition, decreased chronological lifespan, abnormal colony appearance, decreased competitive fitness, decreased growth in the exponential phase, increased heat sensitivity, decreased innate thermotolerance, increased killer toxin resistance, decreased metal resistance, decreased rate of mitotic recombination, increased replicative lifespan, decreased rate of respiratory growth, increased RNA accumulation, increased silencing, decreased telomere length, decreased transposable element transposition, abnormal vacuolar morphology, and decreased rate of vegetative growth. Reduction of function mutants show increased killer toxin resistance. Overexpression of SMI1 results in increased invasive growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources