Literature Help
BIT61 / YJL058C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Karuppasamy M, et al. (2017) Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun 8(1):1729 PMID:29170376
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Bartlett K, et al. (2015) TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity. J Biosci 40(2):299-311 PMID:25963258
- Gaubitz C, et al. (2015) Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Mol Cell 58(6):977-88 PMID:26028537
- Niles BJ and Powers T (2014) TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species. Mol Biol Cell 25(24):3962-72 PMID:25253719
- Liao HC and Chen MY (2012) Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae. J Biol Chem 287(9):6089-99 PMID:22207764
- Pan Y, et al. (2011) Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab 13(6):668-78 PMID:21641548
- Berchtold D and Walther TC (2009) TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell 20(5):1565-75 PMID:19144819
- Daniel JA, et al. (2006) Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics 172(1):53-65 PMID:16157669
- Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 PMID:15689497
- Ho HL, et al. (2005) Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex. Curr Genet 47(5):273-88 PMID:15809876
- Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 PMID:14736892
- Wedaman KP, et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20 PMID:12631735
- Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 PMID:12408816
- Torres J, et al. (2002) Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J Biol Chem 277(45):43495-504 PMID:12171921
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Martinez Marshall MN, et al. (2019) Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Mol Biol Cell 30(12):1555-1574 PMID:30969890
- Hill A, et al. (2018) Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly. Biomolecules 8(2) PMID:29865216
- Misra S and Ray SS (2017) Finding optimum width of discretization for gene expressions using functional annotations. Comput Biol Med 90:59-67 PMID:28941844
- García-Marqués S, et al. (2016) Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status. Biochim Biophys Acta 1863(6 Pt A):1319-33 PMID:27033517
- Kock C, et al. (2016) Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling. Cell Microbiol 18(9):1251-67 PMID:27337501
- Yerlikaya S, et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell 27(2):397-409 PMID:26582391
- Mohammadi S, et al. (2013) Inferring the effective TOR-dependent network: a computational study in yeast. BMC Syst Biol 7:84 PMID:24005029
- Jones CB, et al. (2012) Regulation of membrane protein degradation by starvation-response pathways. Traffic 13(3):468-82 PMID:22118530
- Pracheil T, et al. (2012) TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. Genetics 190(4):1325-39 PMID:22298706
- Spira F, et al. (2012) Patchwork organization of the yeast plasma membrane into numerous coexisting domains. Nat Cell Biol 14(6):640-8 PMID:22544065
- Breitkreutz A, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6 PMID:20489023
- Michelot A, et al. (2010) Reconstitution and protein composition analysis of endocytic actin patches. Curr Biol 20(21):1890-9 PMID:21035341
- Yan Y and Kang B (2010) Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1. Int J Biol Sci 6(4):361-70 PMID:20617129
- Ho HL, et al. (2008) Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling. Eukaryot Cell 7(8):1328-43 PMID:18552287
- Aronova S, et al. (2007) Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae. Mol Biol Cell 18(8):2779-94 PMID:17507646
- Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 PMID:14562095
- Rieger KJ, et al. (1999) Chemotyping of yeast mutants using robotics. Yeast 15(10B):973-86 PMID:10407277
Reviews
No reviews curated.
Download References (.nbib)
- Emmerstorfer-Augustin A and Thorner J (2023) Regulation of TORC2 Function and Localization in Yeast. Annu Rev Cell Dev Biol 39:363-389 PMID:37339679
- Foltman M and Sanchez-Diaz A (2023) TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression. Int J Mol Sci 24(21) PMID:37958727
- Blomberg A (2022) Yeast osmoregulation - glycerol still in pole position. FEMS Yeast Res 22(1) PMID:35927716
- González-Rubio G, et al. (2022) Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity. J Fungi (Basel) 8(4) PMID:35448599
- Thorner J (2022) TOR complex 2 is a master regulator of plasma membrane homeostasis. Biochem J 479(18):1917-1940 PMID:36149412
- Babst M (2020) Regulation of nutrient transporters by metabolic and environmental stresses. Curr Opin Cell Biol 65:35-41 PMID:32200208
- Knudsen JR, et al. (2020) Growth Factor-Dependent and -Independent Activation of mTORC2. Trends Endocrinol Metab 31(1):13-24 PMID:31699566
- Riggi M, et al. (2020) The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance. J Cell Sci 133(9) PMID:32393676
- Tafur L, et al. (2020) Structural Insights into TOR Signaling. Genes (Basel) 11(8) PMID:32759652
- Athanasopoulos A, et al. (2019) Fungal plasma membrane domains. FEMS Microbiol Rev 43(6):642-673 PMID:31504467
- Locke MN and Thorner J (2019) Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. Cell Cycle 18(10):1084-1094 PMID:31068077
- Guaragnella N, et al. (2018) New perspectives from South-Y-East, not all about death. A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017. Microb Cell 5(2):112-115 PMID:29417059
- Zhang W, et al. (2018) Regulation of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 82(1) PMID:29436478
- Pérez-Hidalgo L and Moreno S (2017) Coupling TOR to the Cell Cycle by the Greatwall-Endosulfine-PP2A-B55 Pathway. Biomolecules 7(3) PMID:28777780
- Ribeiro LFC, et al. (2017) Insights regarding fungal phosphoproteomic analysis. Fungal Genet Biol 104:38-44 PMID:28288883
- Erdogan CS, et al. (2016) Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR. Mech Ageing Dev 153:22-9 PMID:26763146
- Olson DK, et al. (2016) Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta 1861(8 Pt B):784-792 PMID:26747648
- Teixeira V and Costa V (2016) Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism. Prog Lipid Res 61:109-33 PMID:26703187
- Hindupur SK, et al. (2015) The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control. Cold Spring Harb Perspect Biol 7(8):a019141 PMID:26238356
- Tsang F and Lin SJ (2015) Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity. Front Biol (Beijing) 10(4):333-357 PMID:27683589
- Conrad M, et al. (2014) Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 38(2):254-99 PMID:24483210
- Rødkaer SV and Faergeman NJ (2014) Glucose- and nitrogen sensing and regulatory mechanisms in Saccharomyces cerevisiae. FEMS Yeast Res 14(5):683-96 PMID:24738657
- De Matteis MA, et al. (2013) Phosphatidylinositol-4-phosphate: the Golgi and beyond. Bioessays 35(7):612-22 PMID:23712958
- Cardon CM and Rutter J (2012) PAS kinase: integrating nutrient sensing with nutrient partitioning. Semin Cell Dev Biol 23(6):626-30 PMID:22245833
- Jazwinski SM (2012) The retrograde response retrograde response and other pathways of interorganelle communication interorganelle communication in yeast replicative aging. Subcell Biochem 57:79-100 PMID:22094418
- Niles BJ and Powers T (2012) Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae. Cell Cycle 11(20):3745-9 PMID:22895050
- Loewith R (2011) A brief history of TOR. Biochem Soc Trans 39(2):437-42 PMID:21428915
- Loewith R and Hall MN (2011) Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189(4):1177-201 PMID:22174183
- Walther TC (2010) Keeping sphingolipid levels nORMal. Proc Natl Acad Sci U S A 107(13):5701-2 PMID:20304791
- Cybulski N and Hall MN (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 34(12):620-7 PMID:19875293
- Dickson RC (2008) More chores for TOR: de novo ceramide synthesis. Cell Metab 7(2):99-100 PMID:18249168
- Jacinto E (2008) What controls TOR? IUBMB Life 60(8):483-96 PMID:18493947
- Jacinto E and Lorberg A (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem J 410(1):19-37 PMID:18215152
- Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60 PMID:18396450
- De Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415 PMID:17041625
- De Virgilio C and Loewith R (2006) The TOR signalling network from yeast to man. Int J Biochem Cell Biol 38(9):1476-81 PMID:16647875
- Inoki K and Guan KL (2006) Complexity of the TOR signaling network. Trends Cell Biol 16(4):206-12 PMID:16516475
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Berchtold D and Walther TC (2009) TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell 20(5):1565-75 PMID:19144819
- Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 PMID:14736892
- Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 PMID:14562095
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Kolhe JA, et al. (2023) The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions. Mol Cell 83(12):2035-2044.e7 PMID:37295430
- Lehner MH, et al. (2022) Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep 41(4):111536 PMID:36288698
- Martinez Marshall MN, et al. (2019) Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Mol Biol Cell 30(12):1555-1574 PMID:30969890
- Hill A, et al. (2018) Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly. Biomolecules 8(2) PMID:29865216
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Karuppasamy M, et al. (2017) Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun 8(1):1729 PMID:29170376
- Zimmermann C, et al. (2017) Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28. G3 (Bethesda) 7(6):1753-1766 PMID:28428242
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Steunou AL, et al. (2016) Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol 36(22):2768-2781 PMID:27550811
- Gaubitz C, et al. (2015) Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Mol Cell 58(6):977-88 PMID:26028537
- Nomura W and Inoue Y (2015) Methylglyoxal activates the target of rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae. Mol Cell Biol 35(7):1269-80 PMID:25624345
- Liao HC and Chen MY (2012) Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae. J Biol Chem 287(9):6089-99 PMID:22207764
- Sharifpoor S, et al. (2012) Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 22(4):791-801 PMID:22282571
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Michelot A, et al. (2010) Reconstitution and protein composition analysis of endocytic actin patches. Curr Biol 20(21):1890-9 PMID:21035341
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Fiedler D, et al. (2009) Functional organization of the S. cerevisiae phosphorylation network. Cell 136(5):952-63 PMID:19269370
- Colomina N, et al. (2008) Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. J Biol Chem 283(42):28670-9 PMID:18667435
- Yu H, et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322(5898):104-10 PMID:18719252
- Daniel JA, et al. (2006) Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics 172(1):53-65 PMID:16157669
- Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 PMID:15689497
- Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 PMID:14736892
- Ito T, et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98(8):4569-74 PMID:11283351
- Uetz P, et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-7 PMID:10688190
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
Download References (.nbib)
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Zhou X, et al. (2021) Cross-compartment signal propagation in the mitotic exit network. Elife 10 PMID:33481703
- MacGilvray ME, et al. (2020) Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res 19(8):3405-3417 PMID:32597660
- Chen YC, et al. (2018) Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife 7 PMID:30516470
- Rødkær SV, et al. (2014) Quantitative proteomics identifies unanticipated regulators of nitrogen- and glucose starvation. Mol Biosyst 10(8):2176-88 PMID:24909858
- Swaney DL, et al. (2013) Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 10(7):676-82 PMID:23749301
- Soulard A, et al. (2010) The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates. Mol Biol Cell 21(19):3475-86 PMID:20702584
- Holt LJ, et al. (2009) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325(5948):1682-6 PMID:19779198
- Albuquerque CP, et al. (2008) A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics 7(7):1389-96 PMID:18407956
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Songdech P, et al. (2024) Increased production of isobutanol from xylose through metabolic engineering of Saccharomyces cerevisiae overexpressing transcription factor Znf1 and exogenous genes. FEMS Yeast Res 24 PMID:38331422
- Carrillo E, et al. (2012) Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30. Mol Biol Cell 23(10):1928-42 PMID:22438580
- Davey HM, et al. (2012) Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability. Environ Microbiol 14(5):1249-60 PMID:22356628
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Butcher RA, et al. (2006) Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol 2(2):103-9 PMID:16415861
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549
- Rieger KJ, et al. (1999) Chemotyping of yeast mutants using robotics. Yeast 15(10B):973-86 PMID:10407277