BCK1 / YJL095W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is heat and cold sensitive, has a decreased fermentative growth rate and a severe respiratory growth defect; null mutant displays increased sensitivity to ER-stress inducing agents (e.g. DTT, tunicamycin and beta-mercaptoethanol) and to cell wall stressors (e.g. caspofungin, congo red, caffeine, calcofluor white and zymolyase treatment); null mutant is sensitive to osmotic and dessication stress; null is sensitive to treatment with various metals, acid and alkaline pH, and killer toxin; null mutant displays decreased mitophagy, delayed pexophagy, and has a strain specific autophagy defect; null mutant has a reduced cell size in saturated culture and a decreased chronological lifespan; heterozygous null is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources