SPT10 / YJL127C Overview

Standard Name
SPT10 1
Systematic Name
CRE1 13 , SUD1 2
Feature Type
ORF , Verified
Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription 2 3 4 6 7
Name Description
SuPpressor of Ty 5
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
660 +/- 397


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all SPT10 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Histone H3 acetylase with a role in cell-cycle specific transcriptional regulation of histone genes via recruitment of SWI/SNF; also implicated in DNA repair, and chromatin silencing at rDNA and mating loci

View computational annotations

Molecular Function

Manually Curated

Cellular Component

Manually Curated
Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

463 total interactions for 397 unique genes

Physical Interactions

  • Affinity Capture-MS: 304
  • Affinity Capture-RNA: 5
  • Co-localization: 3
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions

  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 5
  • Negative Genetic: 17
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 18
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 60
  • Synthetic Rescue: 34
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

Spt10p is a transcriptional activator of histone genes, acting in late G1 to provide sufficient core histones for the assembly of the replicated genome into fresh chromatin. Spt10p binds specifically to histone upstream activating sequence (UAS; 5'-RTTCWDRNWDWTTCKC-3') elements, with the aid of the SBF complex (Swi4 cell cycle box binding factor), and is the only known sequence-specific factor dedicated to histone gene expression. Spt10p forms a homodimer, and two histone UAS elements are required for high-affinity binding by Spt10p. Pairs of histone UAS elements are found only in the major histone promoters. Spt10p contains a sequence-specific DNA-binding domain and a histone acetyltransferase (HAT) domain, but definitive evidence of direct HAT activity has proven elusive. Spt21p stimulates Spt10p binding at all four major histone promoters during S phase, particularly at HTA2-HTB2. Spt10p dissociates from histone promoters by the end of S phase.
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 1999-12-31

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.