GRR1 / YJR090C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

GRR1/YJR090C is a non-essential gene; null mutants are viable, slow-growing, and associated with a range of mutant phenotypes that significantly impact cellular functions and overall fitness. Mutants lacking GRR1 exhibit decreased resistance to both acidic and alkaline pH levels, which may hinder their survival in varying environmental conditions. These mutants show an increased ability to form biofilms, which could affect their interactions with surfaces and other cells. The budding pattern in null mutants is abnormal, characterized by bipolar budding, and bud morphology is also disrupted, indicating potential issues with cell division. Competitive fitness is diminished, leading to reduced viability in resource-limited environments, while desiccation resistance is decreased, making them more vulnerable to dry conditions. The rate of fermentative growth is reduced, and these mutants also exhibit decreased resistance to freeze-thaw cycles. Invasive growth is increased, suggesting an enhanced ability to penetrate surfaces or tissues. Resistance to killer toxins is decreased, and lipid particle morphology is abnormal, which may impact cellular metabolism. Furthermore, oxidative stress resistance is diminished, and respiratory growth is absent, indicating a reliance on fermentation for energy production. UV resistance is also decreased, further underscoring their vulnerability to environmental stressors. Reduced function mutants show an increased rate of fermentative metabolism, suggesting a compensatory mechanism in response to the loss of function. However, when GRR1 is overexpressed, competitive fitness is again decreased, and UV resistance is diminished, indicating that excessive levels of the gene or gene product may also be detrimental.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

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