Phenotype Help

COX17 / YLL009C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant fails to respire and is sensitive to tin and to alkaline pH; overexpression confers increased resistance to clozapine; in large-scale studies, the null mutant shows reduced competitive fitness and sensitivity to desiccation, heat, oxidative stress, and various chemicals; overexpression confers increased filamentous growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

49 entries for 21 phenotypes


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PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
alkaline pH resistance: decreased
classical geneticsnull
Allele: cox17-Δ
S288CMedia: pH 7.5
Serrano R, et al. (2004) PMID:14993228
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: cox17-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test adjusted p < 0.01), showing 2 simultaneous amino acid changes (Z-test, adjusted p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
homozygous diploid, systematic mutation set

glycogen accumulation in diploid mutant strains grown in microtiter plates

null
Allele: cox17-Δ
S288C glycogenWilson WA, et al. (2002) PMID:12096123
chemical compound accumulation: decreased
homozygous diploidnull
Allele: cox17-Δ
S288C0.1 mM potassium tellurite, tellurium atomOttosson LG, et al. (2010) PMID:20675578
chemical compound accumulation: decreased
systematic mutation setnull
Allele: cox17-Δ
S288C isoleucineMülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: increased
systematic mutation setnull
Allele: cox17-Δ
S288C glutamate(1-)Mülleder M, et al. (2016) PMID:27693354
chemical compound excretion: increased
homozygous diploid, systematic mutation set

quantification of extracellular glutathione at stationary phase

null
Allele: cox17-Δ
S288C glutathioneTreatment: SD medium
Details: Fold elevation of glutathione excretion: 2
Perrone GG, et al. (2005) PMID:15509654
competitive fitness: decreased
homozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: cox17-Δ
S288CMedia: YPD
Details: Relative fitness score: 0.973
Deutschbauer AM, et al. (2005) PMID:15716499
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: cox17-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.933
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: cox17-Δ
S288C ethanolQian W, et al. (2012) PMID:23103169
Showing 1 to 10 of 49 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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