SLX4 / YLR135W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

SLX4/YLR135W is a non-essential gene in reference strain S288C. Null mutants are viable but demonstrate several phenotypic abnormalities, including delayed meiotic recombination, decreased mitotic recombination, increased mutation frequency, decreased heat sensitivity, reduced nucleolar size, diminished starvation resistance, and abnormal vacuolar morphology, decreased silencing, and increased competitive fitness. These phenotypes indicate that SLX4 plays a critical role in DNA recombination and repair, nucleolar maintenance, and stress response. Overexpression of SLX4 results in decreased vegetative growth, suggesting that balanced expression of SLX4 is essential for optimal cellular function and growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources