PEP3 / YLR148W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

PEP3/YLR148W is a non-essential gene; null mutants are viable but exhibit a range of phenotypes including decreased resistance to both acidic and alkaline pH, absent autophagy, abnormal bud morphology and budding pattern, decreased chronological lifespan, decreased competitive fitness, absent endocytosis, increased heat sensitivity, decreased resistance to hydrostatic pressure and hyperosmotic stress, decreased killer toxin resistance, decreased metal resistance, absent sporulation, decreased stress resistance, decreased telomere length, decreased toxin resistance, decreased rate of carbon and nitrogen source utilization, and decreased vegetative growth rate. Reduction of function mutants show decreased hyperosmotic stress resistance and abnormal vacuolar transport. Overexpression of PEP3 results in abnormal vacuolar morphology.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources