CSC1 / YLR241W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant shows decreased lifespan, weak heat sensitivity, and decreased competitive fitness on minimal medium, but increased competitive fitness on ethanol, glycerol medium, and oak exudate medium, along with increased resistance to toxic amyloid Aβ42; homozygous diploid null mutant shows reduced resistance to the toxin acrolein and increased resistance to the pesticide toxaphene; overexpression causes reduced vegetative growth, reduced competitive fitness, and reduced resistance to the toxicity of cadmium, copper, manganese, hydroxyurea, diamide, radicicol, fluconazole, and UV light; overexpression in a homozygous diploid leads to enhanced invasive growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources