Phenotype Help

MAP1 / YLR244C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant shows slow growth and decreased replicative lifespan, competitive fitness and cell size; null mutation in homozygous diploid causes abnormal budding pattern and increased sensitivity to low pH, elevated temperatures, hyperosmotic stress, caffeine, hygromycin B, benomyl, DTT

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

71 entries for 28 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
acid pH resistance: decreased
homozygous diploid, systematic mutation setnull
Allele: map1-Δ
S288C hydrogen chlorideMedia: pH 4.5
Mollapour M, et al. (2004) PMID:15334557
alkaline pH resistance: decreased
systematic mutation setnull
Allele: map1-Δ
S288CMedia: pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units
Serrano R, et al. (2004) PMID:14993228
budding pattern: abnormal
homozygous diploid, systematic mutation setnull
Allele: map1-Δ
S288CDetails: >50% of cells exhibited random budding pattern
Ni L and Snyder M (2001) PMID:11452010
cell shape: abnormal
homozygous diploid, large-scale surveynull
Allele: map1-Δ
S288CDetails: round cell shape; moderate defect
Ni L and Snyder M (2001) PMID:11452010
cell size: decreased
systematic mutation set

analysis of cell size for mutants in the systematic deletion collection

null
Allele: map1-Δ
S288CDetails: mutant is among the smallest 5% of haploid deletion strains
Jorgensen P, et al. (2002) PMID:12089449
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: map1-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test adjusted p < 0.01), showing 9 simultaneous amino acid changes (Z-test, adjusted p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
systematic mutation setnull
Allele: map1-Δ
S288C threonineMülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
systematic mutation setnull
Allele: map1-Δ
S288C glutamineMülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
systematic mutation setnull
Allele: map1-Δ
S288C asparagineMülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
systematic mutation setnull
Allele: map1-Δ
S288C aspartate(1-)Mülleder M, et al. (2016) PMID:27693354
Showing 1 to 10 of 71 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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