Phenotype Help

RAD33 / YML011C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

18 entries for 11 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: rad33-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01), showing 1 simultaneous amino acid change (Z-test, adjusted p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: increased
systematic mutation setnull
Allele: rad33-Δ
S288C arginineMülleder M, et al. (2016) PMID:27693354
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: rad33-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.99
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: rad33-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
competitive fitness: decreased
systematic mutation setnull
Allele: rad33-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
competitive fitness: decreased
systematic mutation setnull
Allele: rad33-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: rad33-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0047
Pir P, et al. (2012) PMID:22244311
resistance to chemicals: decreased
systematic mutation set null
Allele: rad33-Δ
S288C2% isobutanolDetails: significant growth reduction relative to wt after treatment with isobutanol
Liu HL, et al. (2021) PMID:34645498
resistance to chemicals: decreased
competitive growth null
Allele: rad33-Δ
S288C0.25 mg/mL acetylsalicylic acidZhu P, et al. (2020) PMID:32049589
resistance to chemicals: decreased
homozygous diploid, competitive growth null
Allele: rad33-Δ
S288C16.4 mM 4-nitroquinoline N-oxideDetails: 2-fold or greater sensitivity to 4NQO treatment based on a fitness defect (FD) score significance threshold of 1.0, expressed as the log2 ratio of a mutant strains fitness relative to control in a chemogenomic screen
Ogbede JU, et al. (2021) PMID:34127714
Showing 1 to 10 of 18 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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