Phenotype Help

SMA2 / YML066C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

24 entries for 12 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
biofilm formation: increased
systematic mutation setnull
Allele: sma2-Δ
Sigma1278bScherz K, et al. (2014) PMID:25009170
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: sma2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.99
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
homozygous diploid, competitive growthnull
Allele: sma2-Δ
S288CTreatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
heat sensitivity: decreased
systematic mutation set

high throughput heat ramp cell death assay

null
Allele: sma2-Δ
S288CTemperature: elevated temperature
Details: ramp temperature from ambient to 30 deg C immediately, hold 1 min at 30 deg C, ramp temperature from 30 deg C to 62 deg C over 20 min, return to ambient
Teng X, et al. (2011) PMID:21814286
metal resistance: decreased
systematic mutation set overexpressionS288C2 mM copper(II) sulfateDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
metal resistance: decreased
homozygous diploid, systematic mutation set null
Allele: sma2-Δ
S288C2.6 mM indium(3+)Treatment: indium chloride, 2.6 mM
Schulze Y, et al. (2023) PMID:37193668
resistance to chemicals: decreased
competitive growthoverexpressionS288C1.3 nM sirolimusDetails: sirolimus is rapamycin
Butcher RA, et al. (2006) PMID:16415861
resistance to chemicals: decreased
systematic mutation setnull
Allele: sma2-Δ
S288C5.5 mg/ml neomycinAlamgir M, et al. (2010) PMID:20691087
resistance to chemicals: decreased
systematic mutation setnull
Allele: sma2-Δ
S288C22 mg/ml amitroleAlamgir M, et al. (2010) PMID:20691087
resistance to chemicals: decreased
homozygous diploid, systematic mutation setnull
Allele: sma2-Δ
S288C0.01 mM glycolaldehydeDetails: > 10% sensitivity relative to the wild-type (p<0.05)
Jayakody LN, et al. (2011) PMID:20960220
Showing 1 to 10 of 24 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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