SEC59 / YMR013C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; conditional class B sec mutant displays reduced N-linked glycosylation and secretion of carboxypeptidase Y, invertase, and alpha-factor; incorporation of myo-inositol and palmitic acid into GPI-membrane anchored proteins is decreased at restrictive temperatures; conditional mutant has reduced membrane levels of dolichyl phosphate, elevated cell wall chitin levels, and decreased resistance to calcofluor white and caspofungin; overexpression results in elevated colony sectoring due to increased mini-chromosome loss; heterozygous diploid null is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources