VPS20 / YMR077C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VPS20/YMR077C is a non-essential gene; null mutants are viable but exhibit a range of phenotypic changes including decreased resistance to both acid and alkaline pH, decreased biofilm formation, increased chronological lifespan, abnormal colony appearance, decreased endocytosis, increased heat sensitivity, decreased hyperosmotic stress resistance, decreased innate thermotolerance, absent invasive and pseudohyphal growth, increased mutation frequency, decreased oxidative stress resistance, abnormal replicative lifespan, decreased RNA accumulation, decreased sporulation efficiency, decreased starvation resistance, abnormal subcellular morphology, decreased survival rate in the stationary phase, decreased telomere length, decreased toxin resistance, decreased transposable element transposition, absent or decreased utilization of carbon sources, decreased utilization rate of nitrogen sources, decreased UV resistance, abnormal vacuolar morphology, and decreased vegetative growth rate. Overexpression of VPS20 results in decreased metal resistance and decreased vegetative growth rate.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources