SRV2 / YNL138W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant exhibits slow growth, an abnormal actin cytoskeleton, and reduced localization of proteins to the bud tip; in large-scale studies, null mutant fails to respire or to mate, has abnormally large cells with elongated buds and abnormal lipid particle morphology, is sensitive to hyperosmotic and oxidative stress, and is resistant to K28 killer toxin and to manganese; conditional mutant exhibits chromosome instability at semi-permissive temperature; overexpression in the Sigma1278b genetic background causes greatly increased filamentous growth; null mutant exhibits filamentous growth in response to HU treatment; diploid heterozygous null mutant is sensitive to starvation and heat; null mutant is sensitive to a variety of chemicals

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources