ATG4 / YNL223W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is unable to undergo autophagy and late nucleophagy, displays reduced mitophagy, and has defects in both micronucleophagy and the CVT pathway; null mutant displays decreased viability during nitrogen starvation and abnormal nuclear morphology; null and reduction-of-function mutants are defective in both the C-terminal modification of Atg8p and its localization to the pre-autophagosomal structure; null mutant has decreased resistance to oxidative stress and zinc treatment, decreased innate thermotolerance and reduced chronological lifespan; null mutant displays decreased glycogen accumulation during stationary phase; homozygous diploid null mutant is unable to sporulate; overexpression results in a decreased growth rate

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources