URE2 / YNL229C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

URE2/YNL229C is a non-essential gene; null mutants are viable but exhibit a range of phenotypic changes including abnormal autophagy, altered chemical compound accumulation and excretion, increased fermentative metabolism rate, altered metal resistance, decreased oxidative stress resistance, abnormal protein/peptide distribution, absent or decreased pseudohyphal growth, increased replicative lifespan, decreased vegetative growth rate, decreased acid and alkaline pH resistance, auxotrophy, decreased biofilm formation, delayed cell cycle progression in the G1 phase, increased cell size, altered competitive fitness, decreased desiccation resistance, decreased fermentative growth rate, increased heat sensitivity, decreased killer toxin resistance, increased stress resistance, decreased telomere length, altered toxin resistance, decreased utilization rates of nitrogen and phosphorus sources, and abnormal vacuolar morphology. Overexpression of URE2 results in increased filamentous growth, altered metal resistance, altered resistance to chemicals, increased toxin resistance, and decreased UV resistance.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources