LTO1 / YNL260C Homology
- Standard Name
- LTO1 1
- Systematic Name
- YNL260C
- SGD ID
- SGD:S000005204
- Feature Type
- ORF , Verified
- Description
- Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion 2 3
- Name Description
- required for biogenesis of the Large ribosomal subunit and initiation of Translation in Oxygen 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
0 entries for 0 homologsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
1 entry for 1 complementIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:17589 | S288C | other complements yeast | Human ORAOV1 does not complement a strain containing a repressible version of LTO1 but co-expression of YAE1D1 and yeast YAE1 homolog YAE1D1 does complement; Co-expression also restores maturation of Rli1p. | SGD | Paul VD, et al. (2015) PMID:26182403 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
8 entries for 8 homologsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Gene name | Description | Source |
|---|---|---|---|---|
| C. gattii WM276 | CGB_F3210C | FungiDB | ||
| C. neoformans var. grubii H99 | CNAG_05716 | FungiDB | ||
| C. neoformans var. neoformans JEC21 | CNF02580 | FungiDB | ||
| S. pombe | SPCC191.08 | PomBase | ||
| C. parapsilosis CDC317 | CPAR2_205430 | Ortholog(s) have role in ribosomal large subunit biogenesis, translational initiation and cytoplasm, nucleus localization | CGD | |
| C. dubliniensis CD36 | CD36_32510 | Ortholog(s) have role in ribosomal large subunit biogenesis, translational initiation and cytosol, nucleus localization | CGD | |
| C. albicans WO-1 | CAWG_01995 | Protein of unknown function | CGD | |
| C. albicans SC5314 | orf19.2367 | Putative protein of unknown function; Hap43-induced; repressed by Rim101; Spider biofilm induced | CGD |
External Identifiers
List of external identifiers for the protein from various database sources.
19 entries for 9 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| orf19.2367 | CGD |
| 4273 | DIP |
| X96722 | GenBank/EMBL/DDBJ |
| Z71536 | GenBank/EMBL/DDBJ |
| 1730633 | GenBank/EMBL/DDBJ |
| 1302313 | GenBank/EMBL/DDBJ |
| 1255958 | GenBank/EMBL/DDBJ |
| CAA65484.1 | GenBank/EMBL/DDBJ |
| CAA96167.1 | GenBank/EMBL/DDBJ |
| 6324069 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi