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PEX6 / YNL329C Protein

Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.

Aliases
PAS8 2
Protein Product
AAA family ATPase peroxin 6
Feature Type
ORF , Verified

AlphaFold Protein Structure

AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.

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Model Confidence

Very high
Confident
Low
Very low

Experimental Data

Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.

Protein Half Life

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ExperimentResultReference
half-life10.0 hrChristiano R, et al. (2014)

Protein Abundance

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Abundance (molecules/cell)MediaTreatmentTreatment timeFold ChangeVisualizationStrain backgroundOriginal ReferenceReference
1551SDuntreatedconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1394SD2 mM 1,4-dithiothreitol2 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1432SD1 mM hydrogen peroxide1 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1496SD minus nitrogencellular response to nitrogen starvation15 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1557SDuntreatedconfocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
Showing 1 to 5 of 17 entries

Domains and Classification - S288C

Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.

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Gene Protein Coordinates Accession ID Description Source No. of Genes with Domain

Domain Locations

Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.

Scroll over a domain to view its exact coordinates and its Description.

Shared Domains

This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray circles); the domains are color-coded according to their source, as displayed in the Domain Locations table, above.

Reset

Click on a gene or domain name to go to its specific page within SGD; drag any of the gene or domain objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram.

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

Pex6-E832A | pex6-Δ

View all PEX6 alleles in SGD search

Sequence

Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence. 

   1 MKASLTFSLS GIYAPCSISR DIYLEYGDKK AECLYGTIRL PQYGPGCTPG KIVHCVLDDS 
  61 LPFCSIVVPS KLFGFMPTQP TMDFCYFEPI LDNVVPVLDS VTFLINEQLY SKLMDLPQEM 
 121 QQIQFLHYKY NINSMETVVH SRDILTSGLC QILNCSPFPQ GLVDFTETQL ILVNDTEQKL 
 181 SALKYANEDE EYALPKIGTN SALSIDLESL PCTISRDLLR PAPHINDDNS IYAFTDAETL 
 241 LRLDVTSGSF ITVSNMGCVR LVKLFVLLLP NGFKKRTIYA PPKIIASFPD CSVVTISKSN 
 301 IGHTDIPIAN QVFISRVGGW LQSQKCFQNI ILTTLKKFFS ESKRILCQND LIPIAFDSSM 
 361 ADLNIAEEND ESDDEDELGQ YYKNDSLVWF FVTSAELDCF SKDNSHFIID PNRTKLITTN 
 421 ITNRRPLPLS RSNLQRYYGF AETFYYDLHI FPYVRQLVNI LETSFNCSQR GITLNASVLL 
 481 HSTTNNVGKA TMVRFASKYL GIHLLEIDCL SLTSNSRQLD STSKIIGYIR AKCENVLPYA 
 541 SPAVIFLAHL DSILLDVNAN QDPEAIKLQK SINFEMSKLL DDFTFKFPGT TFVGSVNNID 
 601 NVPSSFRSHM RFEILVPVPS EAQRLRIFQW YLSSHELNRD VQQKVPVSYM DNISFSSLSS 
 661 YSAGLTPLDI KSIVETARMT ATARFYQESK KCGWLPQSIL ITQEDLSKAT SKARNEFSVS 
 721 IGAPQIPNVT WDDIGGIDFV KGEILDTIDM PLKHPELFTS GMKKRSGILF YGPPGTGKTL 
 781 MAKAIATNFS LNFFSVKGPE LLNMYIGESE ANVRRVFQKA REAKPCVIFF DEIDSVAPKR 
 841 GNQGDSGGVM DRIVSQLLAE LDGMSTDADG VFVIGATNRP DLLDEALLRP GRFDKLLYLG 
 901 IPDTDTKQLN ILEALTRKFV LDNDVKLIEL AKLCPFNYTG ADFYALCSDA MLNAMSRIAR 
 961 MVEKKVSQHN ELTGENISTR RWFDKIATKE DTKVVVKMED FLKAQEQLTP SVSRAELNHY 
1021 EAVRANFEGA *

* Blue amino acids indicate modification sites. More information below.

Post-translational Modifications - S288C

Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.

6 entries for 6 sites

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SiteModificationModifierReference
Y185phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S292phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
K298ubiquitinylated lysineBlaszczak E, et al. (2024) PMID: 38101750
S372phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
T680phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
T1009phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
Showing 1 to 6 of 6 entries

Sequence-Based Physico-chemical Properties - S288C

Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.

Amino Acid Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Amino AcidFrequencyPercentage
A595.73
C212.04
D686.60
E535.15
F585.63
G494.76
H151.46
I767.38
K585.63
L11110.78
M232.23
N555.34
P514.95
Q383.69
R444.27
S908.74
T615.92
V615.92
W60.58
Y333.20

Physical Details

Length (a.a): 1030
Molecular Weight (Da): 115553.4
Isoelectric Point (pl): 5.36
Formula: C5183H8130N1349O1550S44
Aliphatic Index: 90.22
Instability Index: 46.34

Coding Region Translation Calculations

Codon Bias: -0.02
Codon Adaptation Index: 0.12
Frequence of Optimal Codons: 0.42
Hydropathicity of Protein: -0.1
Aromaticity Score: 0.09

Extinction Coefficients at 280nm

ALL Cys residues appear as half cystines: 83420.0
NO Cys residues appear as half cystines: 82170.0

Atomic Composition

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Atom Frequency Percentage

Data not found or not available for  S288C

External Identifiers

List of external identifiers for the protein from various database sources.

26 entries for 10 sources

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External IDSource
AN2925AspGD
orf19.3573CGD
2621DIP
642339GenBank/EMBL/DDBJ
Z71605GenBank/EMBL/DDBJ
L20789GenBank/EMBL/DDBJ
CAA96261.1GenBank/EMBL/DDBJ
CAA58229.1GenBank/EMBL/DDBJ
AAA16574.1GenBank/EMBL/DDBJ
CAA86369.1GenBank/EMBL/DDBJ
Showing 1 to 10 of 26 entries

Resources

Homologs

AGD | AnalogYeast | AspGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY

Protein Databases

AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB

Localization

CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+

Post-translational Modifications

CoSMoS.c. | PhosphoGRID | PhosphoPep