BRE5 / YNR051C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is heat sensitive, displays decreased competitive fitness on numerous growth media, has a decreased ability to utilize glucose as carbon source, and allantoin or glutamine as nitrogen sources; null mutant has abnormal nuclear morphology, filamentous and invasive growth defects, decreased stress resistance and a decreased ability to undergo ribophagy in response to nitrogen starvation; null mutant displays decreased resistance to cell wall stressors, antifungal agents and DNA synthesis inhibitors; null mutant has numerous alterations in the amino acid metabolome; null mutant has an increased replicative lifespan; null mutant has a defect in retrograde transport from the Golgi to the ER; homozygous diploid null displays a defect in meiosis with reduced gene conversion, and abnormal sporulation with an altered DL:LL dityrosine ratio; heterozygous diploid null mutant is haploproficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources