THP1 / YOL072W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

THP1/YOL072W is a non-essential gene; null mutants are viable, slow-growing, and associated with several phenotypes that affect cellular functions and overall fitness. Mutants lacking THP1 exhibit an abnormal budding pattern and delayed cell cycle progression during the G1 phase, which can disrupt normal cell division and growth. These mutants display an abnormal cell shape, indicating potential structural issues within the cells. Cold sensitivity is increased, making them more vulnerable to lower temperatures, while competitive fitness is diminished, leading to reduced viability in resource-limited environments. Resistance to desiccation is decreased, further highlighting their susceptibility to dry conditions. Endocytosis is impaired, which may hinder nutrient uptake and cellular function. Furthermore, these mutants show increased heat sensitivity, indicating a greater susceptibility to elevated temperatures, and decreased resistance to hyperosmotic stress, which can affect their ability to survive in high-salt environments. The morphology of lipid particles is abnormal, potentially impacting cellular metabolism. Metal resistance is also decreased, and mutation frequency is increased, suggesting a higher likelihood of genetic instability. While oxidative stress resistance is increased, prion formation is decreased, indicating a complex relationship between stress responses and protein aggregation. Silencing mechanisms are diminished, which may affect gene regulation, and resistance to starvation is decreased, reflecting challenges in nutrient-scarce conditions. Vacuolar morphology is abnormal, which could disrupt cellular storage and waste management.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

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