WHI2 / YOR043W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

WHI2/YOR043W is a non-essential gene; null mutants are viable and associated with a variety of mutant phenotypes that significantly impact cellular functions and overall organismal health. Mutants lacking this gene exhibit decreased resistance to acidic pH levels, which may hinder their survival in certain environments. The morphology of the actin cytoskeleton is abnormal in these mutants, potentially affecting cellular structure and movement. Additionally, there is an increased rate of apoptosis, suggesting that the absence of WHI2 may lead to heightened programmed cell death. Autophagy processes are also abnormal, which could impair the cell's ability to recycle components and manage stress. These mutants display a decreased cell size and an increased deposition of chitin, indicating alterations in cell wall composition. Their chronological lifespan is reduced, and colony size is smaller, reflecting diminished growth and reproductive capacity. Resistance to desiccation is decreased, making them more vulnerable to dry conditions. Furthermore, endocytosis is impaired, which may affect nutrient uptake. The entry into the G0 stationary phase is abnormal, disrupting the normal lifecycle of the cells. Filamentous growth is decreased, and invasive growth is absent, suggesting limitations in their ability to adapt to certain growth conditions. Heat sensitivity is increased, indicating a greater susceptibility to elevated temperatures. Resistance to hyperosmotic stress and oxidative stress is also decreased, further compromising their resilience. Additionally, these mutants show decreased resistance to starvation and reduced telomere length, which may impact cellular aging and stability. The morphology of mitochondria is abnormal, and mitophagy is decreased, potentially affecting energy production and cellular health. Vacuolar morphology is also abnormal, which could disrupt cellular storage and waste management. Overall, while WHI2 mutants remain viable, their overall fitness and adaptability are significantly impaired, leading to decreased viability in various environmental conditions.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

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