CDC21 / YOR074C Homology
- Standard Name
- CDC21 1 2
- Systematic Name
- YOR074C
- SGD ID
- SGD:S000005600
- Aliases
- CRT9 8 , TMP1 3 , YOR29-25
- Feature Type
- ORF , Verified
- Description
- Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature 3 4 6 7
- Name Description
- Cell Division Cycle 5
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
2 entries for 2 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:29553 | S288C | other complements yeast | Human gene allows growth of the yeast ts mutant at restrictive temperature. | SGD | Kachroo AH, et al. (2015) PMID:25999509 |
| P0A884 | S288C | other complements yeast | E.coli ortholog can complement lethal growth defect and replace yeast ortholog with minimal effect on growth rate | SGD | Kachroo AH, et al. (2017) PMID:28661399 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
25 entries for 9 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| orf19.3549 | CGD |
| 2786 | DIP |
| 2.1.1.45 | ExPASy |
| M29100 | GenBank/EMBL/DDBJ |
| CAA94559.1 | GenBank/EMBL/DDBJ |
| AAA60940.1 | GenBank/EMBL/DDBJ |
| CAA99267.1 | GenBank/EMBL/DDBJ |
| AAA35159.1 | GenBank/EMBL/DDBJ |
| 83578104 | GenBank/EMBL/DDBJ |
| Z74982 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi