Phenotype Help

UFE1 / YOR075W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

16 entries for 11 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
competitive fitness: increased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 1.001
Breslow DK, et al. (2008) PMID:18622397
endoplasmic reticulum morphology: abnormal
classical geneticsconditional
Allele: ufe1-1

R48G, P221L, L282S, L295P

OtherTemperature: elevated temperature, 37 °C
Details: marked accumulation of ER
Lewis MJ and Pelham HR (1996) PMID:8612273
haploinsufficient
heterozygous diploid, systematic mutation set null
Allele: ufe1-Δ
S288COhnuki S and Ohya Y (2018) PMID:29768403
heat sensitivity: increased
classical geneticsconditional
Allele: ufe1-1

R48G, P221L, L282S, L295P

OtherTemperature: elevated temperature, 37 °C
Lewis MJ, et al. (1997) PMID:9214619
inviable
systematic mutation setnull
Allele: ufe1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
inviable
classical geneticsnull
Allele: ufe1-Δ
OtherDowning TA and Storms RK (1996) PMID:8929391
nucleolar morphology: abnormal
systematic mutation set conditional
Allele: ufe1-1

R48G, P221L, L282S, L295P

S288CTemperature: elevated temperature, 37 °C
Details: increased nucleolar fragmentation; high confidence candidate
Neumüller RA, et al. (2013) PMID:23962978
resistance to chemicals: decreased
heterozygous diploid, systematic mutation setnull
Allele: ufe1-Δ
Other sirolimusDetails: sirolimus is rapamycin
Xie MW, et al. (2005) PMID:15883373
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: ufe1-Δ
S288C3 mg/mL histamineLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
systematic mutation setconditional
Allele: ufe1-1
S288C2 ug/mL camptothecinForster DT, et al. (2022) PMID:36192463
Showing 1 to 10 of 16 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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