Literature Help
HES1 / YOR237W Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
- Unique References
- 91
- Aliases
-
OSH5
2
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Muramoto M, et al. (2024) Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy. Biochim Biophys Acta Biomembr 1866(4):184308 PMID:38437942
- Quon E, et al. (2022) ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways. PLoS Genet 18(3):e1010106 PMID:35239652
- Nishimura T, et al. (2019) Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis. Mol Cell 75(5):1043-1057.e8 PMID:31402097
- Tian S, et al. (2018) Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast. J Biol Chem 293(15):5636-5648 PMID:29487131
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Barajas D, et al. (2014) Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites. PLoS Pathog 10(10):e1004388 PMID:25329172
- Ling Y, et al. (2014) Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. Mol Biol Cell 25(21):3389-400 PMID:25165144
- Gebre S, et al. (2012) Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. Cell Cycle 11(11):2176-88 PMID:22622083
- Georgiev AG, et al. (2011) Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM. Traffic 12(10):1341-55 PMID:21689253
- Stefan CJ, et al. (2011) Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell 144(3):389-401 PMID:21295699
- Schulz TA, et al. (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903 PMID:20008566
- Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 PMID:17004323
- Raychaudhuri S, et al. (2006) Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol 173(1):107-19 PMID:16585271
- Wiltschi B, et al. (2006) Sterol binding assay using surface plasmon fluorescence spectroscopy. Anal Chem 78(2):547-55 PMID:16408938
- Beh CT and Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96 PMID:15173322
- Kvam E and Goldfarb DS (2004) Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae. J Cell Sci 117(Pt 21):4959-68 PMID:15367582
- Beh CT, et al. (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40 PMID:11238399
- Jiang B, et al. (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53 PMID:8017104
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Joshua IM, et al. (2023) A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20. Int J Mol Sci 24(21) PMID:37958899
- Sokolov SS, et al. (2022) Structural Role of Plasma Membrane Sterols in Osmotic Stress Tolerance of Yeast Saccharomyces cerevisiae. Membranes (Basel) 12(12) PMID:36557185
- Su B, et al. (2021) Transcriptome Analysis Reveals a Promotion of Carotenoid Production by Copper Ions in Recombinant Saccharomyces cerevisiae. Microorganisms 9(2) PMID:33498600
- Sunyer-Figueres M, et al. (2020) Transcriptomic Insights into the Effect of Melatonin in Saccharomyces cerevisiae in the Presence and Absence of Oxidative Stress. Antioxidants (Basel) 9(10) PMID:33019712
- Sørensen DM, et al. (2019) The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis. Mol Biol Cell 30(9):1069-1084 PMID:30785834
- Iwama R, et al. (2018) Osh6p, a homologue of the oxysterol-binding protein, is involved in production of functional cytochrome P450 belonging to CYP52 family in n-alkane-assimilating yeast Yarrowia lipolytica. Biochem Biophys Res Commun 499(4):836-842 PMID:29621549
- Bühler N, et al. (2015) Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans. Eukaryot Cell 14(9):908-21 PMID:26116213
- Lardenois A, et al. (2015) Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification. Mol Genet Genomics 290(5):2031-46 PMID:25957495
- Maeda K, et al. (2014) A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids. Nat Protoc 9(9):2256-66 PMID:25167057
- Tsanova B, et al. (2014) The RNA exosome affects iron response and sensitivity to oxidative stress. RNA 20(7):1057-67 PMID:24860016
- Vizoso-Vázquez A, et al. (2012) Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response. Appl Microbiol Biotechnol 94(1):173-84 PMID:22189861
- Alfaro G, et al. (2011) The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis. Traffic 12(11):1521-36 PMID:21819498
- Carreto L, et al. (2011) Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains. BMC Genomics 12:201 PMID:21507216
- Momose Y, et al. (2010) Comparative analysis of transcriptional responses to the cryoprotectants, dimethyl sulfoxide and trehalose, which confer tolerance to freeze-thaw stress in Saccharomyces cerevisiae. Cryobiology 60(3):245-61 PMID:20067782
- Rintala E, et al. (2009) Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. BMC Genomics 10:461 PMID:19804647
- Li DY, et al. (2008) Molecular characterization of a novel salt-inducible gene for an OSBP (oxysterol-binding protein)-homologue from soybean. Gene 407(1-2):12-20 PMID:17466467
- van den Brink J, et al. (2008) New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess. BMC Genomics 9:100 PMID:18304306
- Parveen M, et al. (2004) Response of Saccharomyces cerevisiae to a monoterpene: evaluation of antifungal potential by DNA microarray analysis. J Antimicrob Chemother 54(1):46-55 PMID:15201226
- Agarwal AK, et al. (2003) Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. J Biol Chem 278(37):34998-5015 PMID:12824174
- Lehto M, et al. (2001) The OSBP-related protein family in humans. J Lipid Res 42(8):1203-13 PMID:11483621
- Boyer J, et al. (1996) Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae. Yeast 12(15):1575-86 PMID:8972580
- Fang M, et al. (1996) Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J 15(23):6447-59 PMID:8978672
Reviews
No reviews curated.
Download References (.nbib)
- Yu X, et al. (2025) A budding yeast-centric view of oxysterol binding protein family function. Adv Biol Regul 95:101061 PMID:39613716
- Arora A, et al. (2022) Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins. Prog Lipid Res 86:101146 PMID:34999137
- Menegon YA, et al. (2022) How adaptive laboratory evolution can boost yeast tolerance to lignocellulosic hydrolyses. Curr Genet 68(3-4):319-342 PMID:35362784
- Schlarmann P, et al. (2021) Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis. Membranes (Basel) 11(12) PMID:34940472
- Sokolov SS, et al. (2019) Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport. Biochemistry (Mosc) 84(4):346-357 PMID:31228926
- Nagy PD, et al. (2016) Cell-Free and Cell-Based Approaches to Explore the Roles of Host Membranes and Lipids in the Formation of Viral Replication Compartment Induced by Tombusviruses. Viruses 8(3):68 PMID:26950140
- Tong J, et al. (2016) Structural insights into nonvesicular lipid transport by the oxysterol binding protein homologue family. Biochim Biophys Acta 1861(8 Pt B):928-939 PMID:26784528
- Olkkonen VM (2015) OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites. Lipid Insights 8(Suppl 1):1-9 PMID:26715851
- Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-88 PMID:24520995
- Mesmin B, et al. (2013) Insights into the mechanisms of sterol transport between organelles. Cell Mol Life Sci 70(18):3405-21 PMID:23283302
- Olkkonen VM (2013) OSBP-related proteins: liganding by glycerophospholipids opens new insight into their function. Molecules 18(11):13666-79 PMID:24196413
- Olkkonen VM and Li S (2013) Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism. Prog Lipid Res 52(4):529-38 PMID:23830809
- Weber-Boyvat M, et al. (2013) Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism. Biochem Pharmacol 86(1):89-95 PMID:23428468
- Beh CT, et al. (2012) A detour for yeast oxysterol binding proteins. J Biol Chem 287(14):11481-8 PMID:22334669
- Henry SA, et al. (2012) Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. Genetics 190(2):317-49 PMID:22345606
- Johansen J, et al. (2012) Vesicle trafficking from a lipid perspective: Lipid regulation of exocytosis in Saccharomyces cerevisiae. Cell Logist 2(3):151-160 PMID:23181198
- Santos AX and Riezman H (2012) Yeast as a model system for studying lipid homeostasis and function. FEBS Lett 586(18):2858-67 PMID:22824640
- Schuh AL and Audhya A (2012) Phosphoinositide signaling during membrane transport in Saccharomyces cerevisiae. Subcell Biochem 59:35-63 PMID:22374087
- Vihervaara T, et al. (2011) Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters? Chem Phys Lipids 164(6):443-50 PMID:21419754
- Raychaudhuri S and Prinz WA (2010) The diverse functions of oxysterol-binding proteins. Annu Rev Cell Dev Biol 26:157-77 PMID:19575662
- Beh CT, et al. (2009) Yeast oxysterol-binding proteins: sterol transporters or regulators of cell polarization? Mol Cell Biochem 326(1-2):9-13 PMID:19125315
- Mayinger P (2009) Regulation of Golgi function via phosphoinositide lipids. Semin Cell Dev Biol 20(7):793-800 PMID:19508852
- Fairn GD and McMaster CR (2008) Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling. Cell Mol Life Sci 65(2):228-36 PMID:17938859
- Yan D and Olkkonen VM (2008) Characteristics of oxysterol binding proteins. Int Rev Cytol 265:253-85 PMID:18275891
- Schulz TA and Prinz WA (2007) Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family. Biochim Biophys Acta 1771(6):769-80 PMID:17434796
- Olkkonen VM, et al. (2006) The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes? Biochem Soc Trans 34(Pt 3):389-91 PMID:16709169
- Raychaudhuri S and Prinz WA (2006) Uptake and trafficking of exogenous sterols in Saccharomyces cerevisiae. Biochem Soc Trans 34(Pt 3):359-62 PMID:16709161
- Sullivan DP, et al. (2006) Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. Biochem Soc Trans 34(Pt 3):356-8 PMID:16709160
- Olkkonen VM and Levine TP (2004) Oxysterol binding proteins: in more than one place at one time? Biochem Cell Biol 82(1):87-98 PMID:15052330
- Lehto M and Olkkonen VM (2003) The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling. Biochim Biophys Acta 1631(1):1-11 PMID:12573443
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Schulz TA, et al. (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903 PMID:20008566
- Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 PMID:17004323
- Raychaudhuri S, et al. (2006) Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol 173(1):107-19 PMID:16585271
- Wiltschi B, et al. (2006) Sterol binding assay using surface plasmon fluorescence spectroscopy. Anal Chem 78(2):547-55 PMID:16408938
- Beh CT and Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96 PMID:15173322
- Kvam E and Goldfarb DS (2004) Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae. J Cell Sci 117(Pt 21):4959-68 PMID:15367582
- Beh CT, et al. (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40 PMID:11238399
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Muramoto M, et al. (2024) Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy. Biochim Biophys Acta Biomembr 1866(4):184308 PMID:38437942
- Gebre S, et al. (2012) Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. Cell Cycle 11(11):2176-88 PMID:22622083
- Beh CT, et al. (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40 PMID:11238399
- Jiang B, et al. (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53 PMID:8017104
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Carey SB, et al. (2023) A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. G3 (Bethesda) 13(1) PMID:36409020
- Joshua IM, et al. (2023) A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20. Int J Mol Sci 24(21) PMID:37958899
- Mishra PK, et al. (2023) Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability. Mol Biol Cell 34(10):ar99 PMID:37436802
- Weber-Boyvat M, et al. (2021) ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs. Cell Mol Life Sci 78(4):1689-1708 PMID:32734583
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Sørensen DM, et al. (2019) The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis. Mol Biol Cell 30(9):1069-1084 PMID:30785834
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Shulist K, et al. (2017) Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Sci Rep 7(1):11398 PMID:28900268
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Gebre S, et al. (2012) Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. Cell Cycle 11(11):2176-88 PMID:22622083
- Alfaro G, et al. (2011) The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis. Traffic 12(11):1521-36 PMID:21819498
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 PMID:17004323
- Beh CT, et al. (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40 PMID:11238399
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Goh CJH, et al. (2022) Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae. Sci Rep 12(1):10237 PMID:35715465
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Shively CA, et al. (2013) Genetic networks inducing invasive growth in Saccharomyces cerevisiae identified through systematic genome-wide overexpression. Genetics 193(4):1297-310 PMID:23410832
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Vizoso-Vázquez A, et al. (2012) Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response. Appl Microbiol Biotechnol 94(1):173-84 PMID:22189861
- Uluisik I, et al. (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772 PMID:22114689
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61 PMID:21341307
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Butcher RA, et al. (2006) Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol 2(2):103-9 PMID:16415861
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549