VPS16 / YPL045W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VPS16/YPL045W is an essential gene in Sigma1278b and non-essential gene in S288C. Null mutants exhibit a wide range of phenotypic changes including decreased acid and alkaline pH resistance, decreased biofilm formation, altered chemical compound accumulation and excretion, decreased chronological lifespan, decreased competitive fitness, decreased desiccation resistance, decreased endocytosis, increased heat sensitivity, decreased hyperosmotic stress resistance, decreased killer toxin resistance, abnormal lipid particle morphology, decreased metal resistance, decreased mitophagy, decreased oxidative stress resistance, abnormal protein/peptide distribution and modification, altered resistance to chemicals, decreased respiratory growth, decreased reticulophagy, decreased stress resistance, decreased toxin resistance, decreased transposable element transposition, decreased utilization of various carbon and nitrogen sources, abnormal vacuolar morphology, and decreased vegetative growth rate. Reduction of function mutants exhibit decreased hyperosmotic stress resistance, absent vacuolar morphology, and abnormal vacuolar transport.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources