BRO1 / YPL084W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has a growth defect, is heat sensitive, and displays decreased competitive fitness on both fermentative and respiratory growth media; null mutant has a decreased ability to use raffinose as carbon source; null mutant has a reduced ability to target Doa4p to the endosome, an inability to sort MVB cargo protein to the vacuole and a strong vacuolar fragmentation defect; null mutant has decreased resistance to ionic stress, cadmium and manganese treatment, oxidative stress, and desiccation; null mutant is defective in regulating intracellular pH and displays decreased resistance to acid pH; null mutant has decreased telomere length, reduced innate thermotolerance, and a decreased ability to form biofilms; null mutant displays increased accumulation of cadmium, calcium and alanine and decreased accumulation of glycogen; homozygous diploid null mutant has a sporulation defect; heterozygous null mutant is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources