EAF3 / YPR023C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant shows increased biofilm formation, increased lifespan, increased mutation frequency, abnormal utilization of dipeptides, increased protein accumulation, abnormal amino acid profiles, increased excretion of inositol, and increased resistance to acetic and lactic acids, the antifungals cycloheximide and DAPG, the DNA-damaging agents camptothecin and CG-1521, and the pesticide dieldrin ; null mutant shows decreased competitive fitness on minimal, complete, and oak exudate media, though increased fitness on gylcerol medium, decreased filamentous growth, decreased resistance to light stress, decreased utilization of glutamate as a nitrogen source, decreased transposition, and decreased resistance to caffeine, ethanol, rapamycin, MMS, DMSO, hydroxyurea, 6-azauracil, the cancer drug carboplatin, and the fungicide miconazole; heterozygous diploid is haploinsufficient; homozygous diploid null mutant shows increased heat sensitivity and increased resisitance to the pesticide dieldrin; overexpression leads to decreased vegetative growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources