NHP6A / YPR052C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

NHP6A/YPR052C is a non-essential gene in reference strain S288C; null mutants are viable and show compensatory increases in NHP6B mRNA and Nhp6bp protein, with reduced endocytosis. Drug responses are mixed: they are more sensitive to bleomycin and DMSO (and alborixin in heterozygotes), yet more resistant to cycloheximide, fenpropimorph, fluconazole, tebuconazole, and to the toxicity of Aβ42; oxidative stress resistance to paraquat is increased. Competitive fitness is elevated in minimal and synthetic complete media, while heterozygous diploids are haploinsufficient in a turbidostat assay. Overexpression reduces growth rate and can arrest growth under galactose induction.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources