Phenotype Help

DBF20 / YPR111W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutants show increased replicative lifespan and competitive fitness, decreased transposition of transposable elements, and are sensitive to streptomycin, ethanol, and chelator BAPTA; homozygous diploid nulls are sensitive to carcinogen dieldrin; overexpression is lethal due to defects in G2 cell cycle progression and budding

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

17 entries for 10 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
budding index: abnormal
classical geneticsoverexpressionS288CSopko R, et al. (2006) PMID:16455487
cell cycle progression in G2 phase: abnormal
classical geneticsoverexpressionS288CDetails: see Table S8 for more details; shift towards 2C DNA content
Sopko R, et al. (2006) PMID:16455487
competitive fitness: increased
systematic mutation setnull
Allele: dbf20-Δ
S288C ethanolQian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: dbf20-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: dbf20-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.021
Breslow DK, et al. (2008) PMID:18622397
inviable
systematic mutation setoverexpressionS288CSopko R, et al. (2006) PMID:16455487
replicative lifespan: increased
classical geneticsnull
Allele: dbf20-Δ
S288CMcCormick MA, et al. (2015) PMID:26456335
resistance to chemicals: decreased
systematic mutation setnull
Allele: dbf20-Δ
S288C8% ethanolYoshikawa K, et al. (2009) PMID:19054128
resistance to chemicals: decreased
systematic mutation setnull
Allele: dbf20-Δ
S288C1.5 mM BAPTAYadav J, et al. (2007) PMID:17314395
resistance to chemicals: decreased
systematic mutation setnull
Allele: dbf20-Δ
S288C40 mg/ml streptomycinAlamgir M, et al. (2010) PMID:20691087
Showing 1 to 10 of 17 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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