TOM5 / YPR133W-A Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

TOM5/YPR133W-A is a non-essential gene; null mutants exhibit a range of phenotypic abnormalities including decreased resistance to acid pH, decreased biofilm formation, decreased competitive fitness, decreased desiccation resistance, increased heat sensitivity, decreased resistance to hyperosmotic stress, absent invasive growth, abnormal lipid particle morphology, decreased metal resistance, increased mitotic recombination, decreased oxidative stress resistance, decreased replicative lifespan, and a decreased rate of respiratory growth. The utilization of nitrogen sources is also decreased, and vacuolar morphology is abnormal. Conditional mutants display abnormal mitochondrial morphology. Overexpression of TOM5 results in abnormal cell cycle progression in the G1 phase and decreased vegetative growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources