Reference: Siede W and Friedberg EC (1990) Influence of DNA repair deficiencies on the UV sensitivity of yeast cells in different cell cycle stages. Mutat Res 245(4):287-92

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Abstract


Synchronously dividing haploid yeast cells were UV-irradiated in various stages of the cell cycle after release from alpha-factor arrest. In confirmation of earlier results (Chanet et al., 1973), in wild-type strains G1/S phase cells were found to be the most sensitive and late S/G2 cells the most resistant. Stationary-phase (G0) cells were significantly more UV resistant than G1 cells. Strains defective in nucleotide excision repair lost enhanced resistance in the G2 phase and were most UV-sensitive in the G0 state. Reduced G2 resistance was also observed in rad6 mutants but not in rad9 mutants. After UV-irradiation in G1 phase rad9 mutant cells showed a reduced G1/S phase arrest.

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Journal Article | Research Support, U.S. Gov't, P.H.S.
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Siede W, Friedberg EC
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