Longhese MP, et al. (1994)

Abstract

Replication factor A (RF-A) is a heterotrimeric single-stranded-DNA-binding protein which is conserved in all eukaryotes. Since the availability of conditional mutants is an essential step to define functions and interactions of RF-A in vivo, we have produced and characterized mutations in the RFA1 gene, encoding the p70 subunit of the complex in Saccharomyces cerevisiae. This analysis provides the first in vivo evidence that RF-A function is critical not only for DNA replication but also for efficient DNA repair and recombination. Moreover, genetic evidence indicate that p70 interacts both with the DNA polymerase alpha-primase complex and with DNA polymerase delta.

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Reference Type: Journal Article | Research Support, Non-U.S. Gov't
Authors: Longhese MP, Plevani P, Lucchini G
Primary Lit For: RFA1 | RFA3 | RFA2 | DNA polymerase alpha:primase complex | DNA polymerase delta complex
Additional Lit For: rfa1-m2 | rfa1-M4
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