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    Complex: SAGA complex

    Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.


    Curated by
    IntAct
    ComplexAc
    CPX-656
    Systematic Name
    ADA2:ADA3:CHD1:GCN5:HFI1:SGF11:SGF29:SGF73:SPT20:SPT3:SPT7:SPT8:SUS1:TAF10:TAF12:TAF5:TAF6:TAF9:TRA1:UBP8
    SGD ID
    SGD:S000217881
    Aliases
    ADA2-ADA3-CHD1-GCN5-ADA1-SGF11-SGF29-SGF73-ADA5-SPT3-SPT7-SPT8-SUS1-TAF10-TAF12-TAF5-TAF6-TAF9-TRA1-UBP8 complex ; Something about silencing complex ; Spt-Ada-Gcn5 acetyltransferase complex

    Complex Diagram

    This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.


    PDB Structure

    When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.


    3KIK 3KIK 3KJL 3KJL 3M99 3M99 3MHH 3MHH

    Subunits

    This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.


    Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

    Subunit Description Stoichiometry

    Gene Ontology

    Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.


      Molecular Function
    • histone acetyltransferase activity
    • thiol-dependent ubiquitin-specific protease activity
      Biological Process
    • histone acetylation
    • histone deubiquitination
    • regulation of transcription by RNA polymerase II
      Cellular Component
    • SAGA complex

    Shared Annotations

    This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.


    References

    List of references used specifically to curate the information on this page.


    • Pray-Grant MG, et al. (2005) Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433(7024):434-8 PMID: 15647753
      • SGD Paper
      • DOI full text
      • PubMed
    • Rodríguez-Navarro S, et al. (2004) Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116(1):75-86 PMID: 14718168
      • SGD Paper
      • DOI full text
      • PubMed
      • Reference supplement
      • Reference supplement
    • Wu PY, et al. (2004) Molecular architecture of the S. cerevisiae SAGA complex. Mol Cell 15(2):199-208 PMID: 15260971
      • SGD Paper
      • DOI full text
      • PubMed
      • Reference supplement
    • Sterner DE, et al. (2002) SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci U S A 99(18):11622-7 PMID: 12186975
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Pérez-Martín J (1999) Chromatin and transcription in Saccharomyces cerevisiae. FEMS Microbiol Rev 23(4):503-23 PMID: 10422263
      • SGD Paper
      • DOI full text
      • PubMed

    External Identifiers


    IntEnz: 2.3.1.48 | IntEnz: 3.4.19.12
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