Gene Ontology Help

SAGA complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

A transcriptional co-activator complex with histone acetyltransferase activity. Recruited to gene loci by the interaction of TRA1 with specific transcriptional activators, and the bromodomain of GCN5 binds acetylated H3 and H4 N-terminal tails which potentiates cooperative nucleosome acetylation of histone H3 catalysed by the acetylation module. This opens up the chromatin landscape for binding of additional transcription factors and the pre-initiation complex. The DUB module facilitates elongation through deubiquitination of H2B which allows for the recruitment of the CTK1 kinase (Q03957) and subsequent Ser-2 phosophorylation of the Pol II C-terminal domain.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, acyltransferase activity, chromatin binding, histone binding, hydrolase activity, peptidase activity, transferase activity, histone modification, peptidyl-amino acid modification, protein acylation, protein modification by small protein conjugation or removal