Complex: Mitochondrial processing peptidase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1630
- Systematic Name
- MAS1:MAS2
- SGD ID
- SGD:S000217950
- Aliases
- MAS1-Mas2 heterodimer ; MPP complex
- Description
- Metalloprotease which cleaves off the N-terminal presequence from nuclear encoded mitochondrial precursor proteins, such as the sequence that targets the proteins to the mitochondrial matrix. Common features for cleavage of the extension peptides by MPP are a proximal basic amino acid residue, usually arginine at the P2 position, distal N-terminal basic residues generally 3-10 residues from the proximal arginine and an aromatic or less often another type of bulky hydrophobic residue at position P1'; MPP also prefers polar residues such as histidine, serine, and threonine at positions P2' and P3'.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables metalloendopeptidase activity (IDA)
- Biological Process
-
- involved in protein processing involved in protein targeting to mitochondrion (IDA)
- Cellular Component
-
- located in mitochondrion (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
Resources
IntAct | ModelArchive | PDB:1HR6 | PDB:1HR7 ... Show all Show fewer