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Complex: 26S Proteasome complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-2262
Systematic Name
PRE1:PRE2:PRE3:PRE4:PRE5:PRE6:PRE7:PRE8:PRE9:PRE10:PUP1:PUP2:PUP3:RPN1:RPN2:RPN3:RPN5:RPN6:RPN7:RPN8:RPN9:RPN10:RPN11:RPN12:RPN13:RPT1:RPT2:RPT3:RPT4:RPT5:RPT6:SCL1:SEM1
SGD ID
SGD:S000218145
Aliases
Proteasome Activator
Description
Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell. Proteins targeted for degradation are covalently labeled with polyubiquitin chains which are recognized and removed by the proteasome. The core contains the protease active sites (chymotrypsin-like, trypsin-like and peptidylglutamyl-peptide hydrolyzing) that perform the proteolysis reactions in an internal chamber. The regulatory particles act as a discriminating gateway for potential substrates. The base drives the mechanical substrate unfolding and translocation of the unstructured polypeptides into the degradation chamber of the core peptidase. The lid contains the deubiquitinating enzyme (DUB) RPN11 that cleaves polyubiquitin chains from targeted substrates as an essential step in proteasomal substrate processing.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

1G0U 1G0U 1G65 1G65 1JD2 1JD2 1RYP 1RYP 1Z7Q 1Z7Q 2F16 2F16 2FAK 2FAK 2GPL 2GPL 2ZCY 2ZCY 3BDM 3BDM 3D29 3D29 3DY3 3DY3 3DY4 3DY4 3E47 3E47 3GPJ 3GPJ 3GPT 3GPT 3GPW 3GPW 3HYE 3HYE 3JCK 3JCK 3JCO 3JCO 3JCP 3JCP 4CR2 4CR2 4CR3 4CR3 4CR4 4CR4 4V7O 4V7O

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

EMDB: 2594 | EMDB: 2595 | EMDB: 2596 | IntEnz: 3.4.19.12 | IntEnz: 3.4.25.1

Resources

IntAct | ModelArchive | PDB:1G0U | PDB:1G65 | PDB:1JD2 | PDB:1RYP | PDB:1Z7Q | PDB:2F16 | PDB:2FAK | PDB:2GPL | PDB:2ZCY ... Show all