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Gene Ontology Help

26S Proteasome complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell. Proteins targeted for degradation are covalently labeled with polyubiquitin chains which are recognized and removed by the proteasome. The core contains the protease active sites (chymotrypsin-like, trypsin-like and peptidylglutamyl-peptide hydrolyzing) that perform the proteolysis reactions in an internal chamber. The regulatory particles act as a discriminating gateway for potential substrates. The base drives the mechanical substrate unfolding and translocation of the unstructured polypeptides into the degradation chamber of the core peptidase. The lid contains the deubiquitinating enzyme (DUB) RPN11 that cleaves polyubiquitin chains from targeted substrates as an essential step in proteasomal substrate processing.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, hydrolase activity, peptidase activity, catabolic process, proteolysis involved in protein catabolic process

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.