HYP2 / YEL034W Homology
- Standard Name
- HYP2 1
- Systematic Name
- YEL034W
- SGD ID
- SGD:S000000760
- Aliases
- eIF5A , eIF-5A 11 , TIF51A 11
- Feature Type
- ORF , Verified
- Description
- Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has paralog ANB1 that arose from whole genome duplication; in humans EIF5A variants cause a disorder characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphism; human EIF5A complements inviability of yeast hyp2 anb1 double null mutant 2 3 4 5 6 7 8 9 10
- Name Description
- HYPusine-containing protein 1
- Paralog
- ANB1 8
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
5 entries for 5 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| FB:FBgn0285952 | S288C | other complements yeast | Heterologous expression of D.melanogaster eIF5A restores growth and shmoo formation of yeast eIF5A mutant cells | SGD | Muñoz-Soriano V, et al. (2017) PMID:28852021 | |
| Homo sapiens | HGNC:3300 | S288C | other complements yeast | P-POD | Magdolen V, et al. (1994) PMID:7969034 | |
| Homo sapiens | HGNC:3300 | S288C | other complements yeast | Human EIF5A complements the inviability of the yeast hyp2 null mutant. | SGD | Koettnitz K, et al. (1995) PMID:7622067 |
| Homo sapiens | HGNC:3300 | S288C | other complements yeast | Human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant. | SGD | Schwelberger HG, et al. (1993) PMID:8314769 |
| Homo sapiens | HGNC:3300 | S288C | other complements yeast | Proliferation of hyp2 strains harboring SUMOylation mutants was reduced in comparison with eIF5A1-WT-harboring hyp2 thermosensitive strains at restrictive temperature, indicating that SUMOylation-deficient eIF5A1 alleles cannot completely complement HYP2 function in yeast, despite being expressed at protein levels comparable to the wild-type eIF5A | SGD | Seoane R, et al. (2024) PMID:38229033 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
31 entries for 10 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| AN4015 | AspGD |
| orf19.3426 | CGD |
| 4230 | DIP |
| CAA39693.1 | GenBank/EMBL/DDBJ |
| AAA35155.1 | GenBank/EMBL/DDBJ |
| AAB65008.1 | GenBank/EMBL/DDBJ |
| BAA11826.1 | GenBank/EMBL/DDBJ |
| U18779 | GenBank/EMBL/DDBJ |
| 398364255 | GenBank/EMBL/DDBJ |
| M63541 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | AnalogYeast | AspGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi