GPA1 / YHR005C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

GPA1/YHR005C is a non-essential gene; null mutants exhibit increased cell size, abnormal cell shape, and abnormal liquid culture appearance. They are viable with increased chronological lifespan and overall lifespan, but show absent respiratory growth, decreased sporulation efficiency, decreased starvation resistance, and decreased vegetative growth. Null mutants are impaired in mating response. Repressible mutants display arrested and abnormal cell cycle progression in the G1 phase, abnormal cell shape, and abnormal nuclear position. Reduction of function mutants show decreased competitive fitness and absence of pheromone-induced cell cycle arrest. Overexpression of GPA1 results in abnormal nuclear position and decreased pheromone sensitivity. Activation mutants exhibit arrested cell cycle progression, decreased protein transport, and decreased vegetative growth. Conditional mutants show arrested cell cycle progression in the G1 phase, increased heat sensitivity, decreased nuclear fusion during mating, abnormal nuclear position, abnormal protein/peptide distribution, and increased RNA accumulation.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources