TUB2 / YFL037W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; heterozygous diploid null mutants have unstable chromosomes and are sensitive to cancer drugs; some conditional mutants are resistant to microtubule-destabilizing agent benomyl but senstive to heat, and undergo cell-cycle arrest as large-budded cells; overexpression interferes with mitotis and slows growth in some strain backgrouds, is lethal in others; cells heterozygous for a reduced function allele analogous to human mutation associated with congenital fibrosis of the extraocular muscles (CFEOM) are sensitive to benomyl

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources