BIR1 / YJR089W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene in some strain backgrounds and non-essential in others; deletion and overexpression result in elevated rates of chromosome loss and missegregation; conditional mutant has a chromosome biorientation defect; heterozygous null mutant has a growth defect, displays elevated polyploidy and grossly altered morphology; CDK phosphorylation site mutant has short anaphase spindles and is unable to properly localize Cbf2p/Ndc10p to the anaphase spindle and midzone; conditional mutant mislocalizes both Bub1p and Ipl1p, and has decreased levels of Pds1p; conditional mutant displays increased oxidative stress-induced apoptosis, while overexpression reduces apoptosis; overexpression results in a growth advantage; diploid null mutant has delayed and inefficient sporulation while the haploid null mutant has a severe spore germination defect; homozygous diploid null mutant forms pseudohyphal structures in sporulation media

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources